Correlation between Human Leukocyte Antigen Gene Polymorphism and COVID-19: Incidence and Severity | Chapter 11 | Challenges and Advances in Pharmaceutical Research Vol. 7

 Age and the existence of coexisting metabolic disorders such obesity, diabetes, and hypertension have been identified as risk factors for the severity of coronavirus disease-2019 (COVID-19) infection. To emphasise the potential impact of human leukocyte antigen gene variation on the treatment of COVID-19 patients, a literature search was conducted. It was found that human leucocyte antigens and a higher risk of COVID-19 might be related. Additionally, both HLA-G and HLA-E might cause immunological tolerance. They could, in fact, block innate and adaptive immune reactions. An aggravated immune response brought on by viral infection in the host is the main factor in the pathophysiological processes of SARS-CoV-2. In severe cases, an overpowering immune response leads to an inflammatory cytokine storm that seriously damages tissue and leads to multiple organ failures.

Author(s) Details:

Mohamed Ahmed Raslan,
Drug Research Center, Cairo, Egypt and  Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Egypt.

Eslam Mansour Shehata,
Drug Research Center, Cairo, Egypt.

Sara Ahmed Raslan,
Drug Research Center, Cairo, Egypt.

Nagwa Ali Sabri,
Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Egypt.

Please see the link here: https://stm.bookpi.org/CAPR-V7/article/view/8374