Circulating Biomarkers in Arterial Aneurysms | Chapter 1 | Current Progress in Medicine and Medical Research Vol. 9

Arterial aneurysms are a weighty medical condition associated with extreme morbidity and death. The degenerative disease process, generally driven by atherosclerosis and age-connected changes in blood vessel structure, leads to the local dilation of channels. This chapter focuses on the role of flowing biomarkers in predicting and directing arterial aneurysms, with a particular importance on peripheral and intestinal aortic aneurysms in the Indian population. The objective is to recognize specific biomarkers that can be used to anticipate aneurysm rupture by analysing blood samples from victims. Matrix metalloproteinase-9 (MMP-9), plasma fibrinogen, D-dimer, interleukin-6 (IL-6), and C-reactive protein (CRP) are checked as potential biomarkers. The findings from our study take care of contribute to the development of enhanced diagnostic finishes and treatment strategies for arterial aneurysms, eventually enhancing patient consequences and reducing the burden of this condition on community health.

Author(s) Details:

Rohit Kumar Singh,
Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University Varanasi, Uttar Pradesh, India.

Mohd Zeeshan Hakim,
Department of CTVS, KGMU, Lucknow, Uttar Pradesh, India.

Ajay K. Khanna,
Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University Varanasi, Uttar Pradesh, India.

Please see the link here: https://stm.bookpi.org/CPMMR-V9/article/view/11685

Correlation between Human Leukocyte Antigen Gene Polymorphism and COVID-19: Incidence and Severity | Chapter 11 | Challenges and Advances in Pharmaceutical Research Vol. 7

 Age and the existence of coexisting metabolic disorders such obesity, diabetes, and hypertension have been identified as risk factors for the severity of coronavirus disease-2019 (COVID-19) infection. To emphasise the potential impact of human leukocyte antigen gene variation on the treatment of COVID-19 patients, a literature search was conducted. It was found that human leucocyte antigens and a higher risk of COVID-19 might be related. Additionally, both HLA-G and HLA-E might cause immunological tolerance. They could, in fact, block innate and adaptive immune reactions. An aggravated immune response brought on by viral infection in the host is the main factor in the pathophysiological processes of SARS-CoV-2. In severe cases, an overpowering immune response leads to an inflammatory cytokine storm that seriously damages tissue and leads to multiple organ failures.

Author(s) Details:

Mohamed Ahmed Raslan,
Drug Research Center, Cairo, Egypt and  Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Egypt.

Eslam Mansour Shehata,
Drug Research Center, Cairo, Egypt.

Sara Ahmed Raslan,
Drug Research Center, Cairo, Egypt.

Nagwa Ali Sabri,
Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Egypt.

Please see the link here: https://stm.bookpi.org/CAPR-V7/article/view/8374

An Experimental Rat Model of Acute Pancreatitis and the Effect of Apigenin| Chapter 10 | New Horizons in Medicine and Medical Research Vol. 11

 By assessing the levels of interleukin-6 (IL-6), interleukin-18 (IL-18), resistin (R), and CD45 in blood and high mobility group box 1 protein (HMGB1) in intestinal tissue using a rat experimental model, the study's goal was to determine the impact of apigenin (AP) on acute pancreatitis (ACP). We employed 126 male Wistar rats and put them into three groups: Apigenin (A), Control (C), and Sham (S) (Ap). The abdominal wall was closed and a laparotomy was performed on the S group. The pancreatic duct was severed to cause acute pancreatitis in the C group. After ACP was introduced, AP was given to the apigenin group. We gathered blood and intestinal tissue. Following AP delivery, intestinal tissue levels of HMGB1 and CD45 as well as IL-6 and IL-18 in the blood were reduced. R, however, continued to be at low levels in the Ap group. In an animal model of bilio-pancreatic duct ligation, AP therapy appears to preserve serum and intestinal parameters, reducing the severity of ACP. Giving this material to people might thus lessen the harm done to the organs that are afflicted in the early stages of ACP.

Author(s) Details:

Sovatzidis Apostolos,
Faculty of Medicine, Democritus University of Thrace, Alexandoupolis, 68100-Greece.

Oikonomou Panagoula,
Faculty of Medicine, Democritus University of Thrace, Alexandoupolis, 68100-Greece and  Department of Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis-68100 Greece.

Nikolaidou Eirini,
Department of Plastic, Reconstructive and Hand Surgery & Burns ICU, General Hospital of Thessaloniki “G. Papanikolaou”, Thessaloniki, 57010-Greece.

Lambropoulou Maria,
Laboratory of Histology and Embryology, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, 68100-Greece.

Papachristou Fotini,
Laboratory of Experimental Surgery and Surgical Research, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, 68100-Greece.

Papalois Apostolos,
Educational and Research Center ELPEN, 19009- Greece.

Tsalikidis Christos,
Faculty of Medicine, Democritus University of Thrace, Alexandoupolis, 68100-Greece and Department of Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis-68100 Greece.

Tsaroucha K. Alexandra,
Faculty of Medicine, Democritus University of Thrace, Alexandoupolis, 68100-Greece and Department of Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis-68100 Greece and Laboratory of Experimental Surgery and Surgical Research, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, 68100-Greece.

Please see the link here: https://stm.bookpi.org/NHMMR-V11/article/view/7145