Determining the Levels of Glycated Hemoglobin, Serum Calcium, Magnesium, Phosphate, Uric Acid and Microalbuminuria in Patients with Newly Diagnosed Type 2 Diabetes Mellitus | Chapter 15 | Recent Developments in Medicine and Medical Research Vol. 11

 

Background: Over the previous three decades, the global prevalence of diabetes mellitus has more than doubled, making it one of the most important public health challenges affecting all countries. As a result, researchers compared HbA1c, serum calcium, serum magnesium, serum phosphate, serum uric acid, and microalbuminuria levels in newly diagnosed type 2 diabetes mellitus patients to normal healthy people.

Methods: This was a cross-sectional study done in the Department of Biochemistry at SKIMS-MC&H, Bemina, Srinagar. The 300 people who took part in this study were divided into two groups. Group I: consisted of 150 healthy men and women between the ages of 30 and 80. A total of 150 newly diagnosed Type 2 diabetes mellitus patients in the same age group made up Group II. Fasting blood samples were tested for calcium, magnesium, phosphorus, uric acid, blood sugar, and HbA1c. To evaluate microalbuminuria, urine was collected for 24 hours and the results were compared to those of healthy people. The standard deviation of the means was calculated, and the significance level was determined using the student t-test.

FBS, HbA1c, calcium, magnesium, phosphate, and uric acid levels in the blood were 89.71 9.22, 4.68 0.47, 9.61 0.84, 2.23 0.41, 3.45 0.46, 4.21 1.04 in controls (group-I) and 145.57 76.61, 8.94 2.38, 8.09 0.18, 1.92 0.27, 2.82 0.68, 7.01 0.27 in patients (group-II) (0.001). The mean difference in microalbuminuria between patients and controls was 35.01 41.30 and 15.35 2.60 (0.001).

Conclusion: There is a decrease in serum calcium, magnesium, and phosphate levels, which are all important in blood glucose management. As a result, oral supplementation of all of these ions is recommended in addition to food. Reduced glucose tolerance was linked to higher serum uric acid and microalbuminuria, therefore these parameters should be assessed early in the course of Type-2 diabetes monitoring to help reduce the risk of kidney issues. Glycated haemoglobin levels can also indicate early patient mobilisation to diabetic support services, treatment, and medication response, all of which can help to avoid micro and macro complications associated with uncontrolled Type-2 diabetes.

Author(S) Details

Qazi Najeeb Ahmad
Department of Biochemistry, Govt. Medical College Anantnag (J&K), India.

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