Background: Pancytopenia is a common ailment that manifests itself in a variety of ways around the world. Primary investigations for evaluating and diagnosing the causes of pancytopenia include bone marrow aspiration and biopsy. However, before performing a bone marrow aspiration or biopsy, it's worth noting that the newer reticulocyte indices, such as reticulocyte percent and absolute reticulocyte count, provided by automated cell counters, can help us get a better picture of marrow erythropoietic activity while avoiding inter-observer variability. The Immature Reticulocyte Fraction (IRF), Reticulocyte Hemoglobin Content (CHr or Ret-He), and the differential between reticulocyte and erythrocyte haemoglobin content are some of the newer reticulocyte indices (Delta-He). IRF was first used to track hematopoietic treatment in children with pancytopenia caused by cancer chemotherapy. We tried to emphasise the importance of Immature Reticulocyte Fraction (IRF) above other reticulocyte indices in pancytopenia diagnosis and therapy response assessment.
The history of the patients was taken in this investigation. Then, using Automated Cell Counters (Sysmex XT-4000i), EDTA mixed blood was studied, followed by a bone marrow investigation to validate the cause. The results were statistically calculated.
We discovered that IRF levels were also important in the diagnoses of Megaloblastic Anaemia, Aplastic Anaemia, early Marrow Recovery after Suppression, Hemolytic Disease, and Chronic Diseases.
Conclusion: The absolute reticulocyte count is a quantitative indicator of the efficacy of erythropoiesis, and the IRF is thought to be an index of acceleration. As a result, after starting treatment, monitoring both IRF and Reticulocyte Count on a regular basis may be beneficial in determining the efficacy of the treatment.Author(S) Details
Suchandra Ray
Department of Pathology IPGME&R, Kolkata, West Bengal, India.
Chhanda Das
Department of Pathology IPGME&R, Kolkata, West Bengal, India.
Sudip Roy
Department of Pathology IPGME&R, Kolkata, West Bengal, India.
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