Depression is a multifaceted mood disorder that has been classified and treated in numerous ways. Despite the fact that a number of synthetic drugs are used as standard treatment for clinically depressed patients, they have side effects that can jeopardize the therapeutic treatment. For thousands of years, many plants and formulations have been used to treat depression in traditional medical systems. Commiphora mukul is a widely available plant in India, and traditional literature claims that it is a valuable plant against a wide range of diseases. There was no scientific evidence of this plant's antidepressant activity until now. As a result, the current study was designed to look into the effect of Commiphora mukul (Family: Burseraceae) on depression in mice using the tail suspension test (TST) and the forced swim test (FST). Guggul hydro-alcoholic, ethyl acetate, and pet ether fractions (50 and 100 mg/kg p.o.) administered orally for 14 consecutive days significantly reduced immobility periods in both TST and FST in a dose-dependent manner, demonstrating significant antidepressant-like activity. In both FST and TST, the fractions' activities were found to be comparable to imipramine. Finally, our findings suggest that Commiphora mukul has the potential to be used as an adjuvant in the treatment of depression.
Author(s) Details
Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India.
Sarath Nalla
University college of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.
View Book :- https://stm.bookpi.org/TIPR-V7/article/view/1846
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