Microencapsulation of Zidovudine Using Colophony: Confirming Natural Resin as Microparticulate Drug Carrier | Chapter 4 | Technological Innovation in Pharmaceutical Research Vol. 5

The goal of this work was to create and test natural biodegradable zidovudine (AZT) microcapsules using colophony resin as the microencapsulating agent. For the manufacture of different batches of microcapsules, an industrially feasible emulsification-solvent evaporation approach was adopted. Particle morphology, microencapsulation efficiency, manufacturing yield, micromeritic characteristics, release profile and release kinetics, and other aspects of the proposed system were examined in vitro. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), and infrared spectroscopy were used to assess the physical and chemical properties of AZT and AZT-loaded microcapsules (FTIR). The microcapsules with resin coatings were found to be spherical, distinct, and free-flowing. The microencapsulation efficiency was within a tight range (91-97%), implying that drug distribution was consistent between batches. The solid state of AZT was partially modified, according to DSC and XRD data. Depending on the core:coat ratio, zidovudine release from optimised batches of resin coated microcapsules took up to 24 hours. The Fickian diffusion process was discovered to be responsible for drug release. The thickness of the walls was found to grow as the resin concentration increased. The permeability constant values were discovered to be decreasing as the t50 percent values of various formed batches increased. The resin-coated microcapsules had good controlled release properties and were determined to be suitable for a once-daily oral controlled release product.

Author (s) Details

Dr. Satyajit Panda
Department of Pharmaceutics, Institute of Pharmacy and Technology, Salipur, Cuttack (Odisha) – 754202, India.

Dr. Snigdha Pattnaik
School of Pharmaceutical Sciences, Siksha O Anusandhan University, Jagmohan Nagar, Jagamara, Bhubaneswar (Odisha), India.

Dr. Laxmidhar Maharana
School of Pharmaceutical Sciences, Siksha O Anusandhan University, Jagmohan Nagar, Jagamara, Bhubaneswar (Odisha), India.

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