Multi‐omics usually refers to the crossover application of
multiple high‐throughput screening technologies, which play a great role in
promoting the study of human diseases. With the advancement of DNA sequencing
technology, biological analysis is done using multiple omes such as Genome,
Proteome, Transcriptome, Epigenome, Metabolome, etc. Recently, another biological technique known
as DNA Adductome has been used to detect the cause of DNA damage done by many
chemical agents, drugs, pollutants, etc. Details of Next Generation Technology
and Alignment technology have been discussed in this study. The application of
Next Generation Sequencing (NGS) technology has been applied for the
improvement of crop plants.
When DNA is bound to any chemical, it is called a DNA
Adduct, and the discipline is called DNA –DNA-Adductomes. The adduct formation leads to DNA damage
resulting in mutation. The origin of many human diseases, like cancer and
others, has been found to be due to the formation of DNA adducts. The study of
DNA adducts has great potential in noting the carcinogenic effects of toxic
chemicals, their mode of action and the damage caused by these chemicals, as
well as to identify the marker. The way of adduct formation in DNA has been
discussed with special reference to human health. The measurement and
identification of environmental pollutants can be monitored through the study
of DNA adducts. Thus, this multiomic technology, including DNA Adductomes, may
bring a revolution in medicine and toxicological studies.
Author(s) Details
Professor Satyesh
Chandra Roy
Department of Botany, Centre of Advanced Study for Cell and Chromosome
Research, University of Calcutta, India.
Please see the book here:- https://doi.org/10.9734/bpi/mono/978-81-989371-7-9/CH2
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