Background: The severe acute respiratory syndrome coronavirus 2 is
the cause of the global pandemic known as COVID-19 (SARS-COV-2), which has
captivated the entire world. It has been
demonstrated that the coronavirus interacts with the angiotensin-converting
enzyme-2 (ACE-2) present in skeletal muscles, increasing its susceptibility to
direct viral invasion. The fibrotic activity of muscle fibroblasts increases,
aggravating the inflammatory response. The participants exhibit musculoskeletal
complaints, including fatigue, myalgia, arthralgia, muscle weakness, decreased
bone mineral density, and anomalies in soft tissues. Further examination of
COVID-19 individuals showed elevated levels of creatine phosphokinase, myalgia,
and arthritic changes, including myositis. A long-term study found that the
most common musculoskeletal complaints between two weeks and one month after
hospitalization were myalgia, arthralgia, and fatigue. The current study's goal
is to analyze various musculoskeletal concerns in COVID-19 participants.
Outcome Measures: A standard Nordic musculoskeletal questionnaire
will be taken for all subjects. Depending on the problem and joint involved
outcome measures like NPDI, SPADI, DASH, OLBDQ, HHS, WOMAC, FADI, CFS, LEFS,
and FAS will be used.
Statistical Analysis: Descriptive statistical analysis like mean,
and standard deviation will be done by using SPSS’s latest version software by
taking the help of a Biostatistician after ensuring the normal distribution and
analysis. To find out the association between two variables Fisher’s exact test
and Pearson chi-square test will be used.
Results: The results of this study will also be important for
subjects affected with COVID-19 symptoms to better understand their long-term
musculoskeletal problems with a duration of more than 3 months from affection
with the virus which may or may not affect their functional performance and
physical activity levels.
Conclusion: This study will be helpful in finding the prevalence
of musculoskeletal problems among post-COVID-19 subjects. If any particular
symptoms are found to be more prominent strategies to cope and manage those
symptoms in COVID-19 subjects can be developed in the future by doing further
research.
Clinical Trial Registration: The study is registered with the
Clinical Trials Registry- India (CTRI), with the registration number for the
trial being CTRI/2022/08/ 044661.
Author(s) Details
Noel
Samuel Macwan
College of Physiotherapy, Sumandeep Vidyapeeth (Deemed to be
University), Piparia, Waghodia, Vadodara, Gujarat, 391760, India.
Kalpana
Vasava
College of Physiotherapy, Sumandeep Vidyapeeth (Deemed to be
University), Piparia, Waghodia, Vadodara, Gujarat, 391760, India.
Please
see the book here:- https://doi.org/10.9734/bpi/dhrni/v2/1256
No comments:
Post a Comment