Alveolar bone remodelling is a dynamic and continuous
process involving bone resorption and formation, essential for preserving oral
health, maintaining structural integrity, and supporting functional dentition.
This adaptive mechanism enables the alveolar bone to respond to mechanical
stimuli such as mastication and orthodontic forces, playing a critical role in
both periodontal maintenance and orthodontic therapy. The remodelling process
is governed by a coordinated interplay of cellular, molecular, and systemic
factors. Osteoclasts facilitate bone resorption, while osteoblasts are
responsible for new bone formation. Osteocytes, which are mature osteoblasts
embedded within the bone matrix, act as mechanosensors and help regulate bone
turnover in response to mechanical stress. Central to this regulatory network
is the RANKL–OPG (Receptor Activator of Nuclear Factor Kappa-Β Ligand –
Osteoprotegerin) signalling pathway, which modulates the balance between
resorption and formation. Recent advances in alveolar bone regeneration have been
made possible by recent developments in regenerative treatment, including the
use of growth factors (e.g., BMPs, PDGF), stem cell-based techniques, and
biomimetic scaffolds. In order to improve the results of periodontal therapy,
orthodontics, and implant dentistry, these treatments seek to restore bone
volume and architecture in areas that have been weakened by illness, trauma, or
tooth loss. A deeper understanding of the cellular and molecular mechanisms
involved in bone remodelling, combined with the integration of regenerative
strategies, holds significant promise for promoting bone health, preserving
tooth stability, and enhancing long-term clinical outcomes.
Author(s) Details
Dr. Jayachandiran. M
Department of Periodontology, Indira Gandhi Institute of Dental Sciences,
Sri Balaji Vidyapeeth (SBV) (Deemed - to - be - University), Mahatma Gandhi
Medical College Campus, Pondy - Cuddalore Main Road, Pillaiyarkuppam,
Puducherry – 607402, India.
Dr. Saravana Kumar.R
Department of Periodontology, Indira Gandhi Institute of Dental Sciences,
Sri Balaji Vidyapeeth (SBV) (Deemed - to - be - University), Mahatma Gandhi
Medical College Campus, Pondy - Cuddalore Main Road, Pillaiyarkuppam,
Puducherry – 607402, India.
Dr. Pratebha.B
Department of Periodontology, Indira Gandhi Institute of Dental Sciences,
Sri Balaji Vidyapeeth (SBV) (Deemed - to - be - University), Mahatma Gandhi
Medical College Campus, Pondy - Cuddalore Main Road, Pillaiyarkuppam,
Puducherry – 607402, India.
Dr. Sakthi Devi.S
Department of Periodontology, Indira Gandhi Institute of Dental Sciences,
Sri Balaji Vidyapeeth (SBV) (Deemed - to - be - University), Mahatma Gandhi
Medical College Campus, Pondy - Cuddalore Main Road, Pillaiyarkuppam,
Puducherry – 607402, India.
Dr. Kurinchichelvan.R
Department of Periodontology, Indira Gandhi Institute of Dental Sciences,
Sri Balaji Vidyapeeth (SBV) (Deemed - to - be - University), Mahatma Gandhi
Medical College Campus, Pondy - Cuddalore Main Road, Pillaiyarkuppam,
Puducherry – 607402, India.
Please see the book here:- https://doi.org/10.9734/bpi/mono/978-81-990309-8-5
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