The presented material presents the results of studies performed on
N-(phosphonomethyl)glycine (NPMG). This compound is the active ingredient of
the most widely used herbicide in agricultural practice, Roundup (Glyphosate;
Tornado; and many others). The presented study investigates the behaviour and
toxicological impact of NPMG, the active ingredient in widely used herbicides
such as Roundup, Glyphosate, and Tornado. To assess the hazard of photochemical
decomposition products formed under the influence of solar ultraviolet
radiation and ozone, NPMG was exposed to hard UV radiation with λ = 250-600 nm
with simultaneous bubbling with ozone. After 14.3 hours, NPMG is practically
not identified in the solution. The decomposition process is complex and
multistage. The toxicological effect of aqueous solutions of NPMG and the
products of its photochemical decomposition was studied on test objects:
luminous bacteria of the Ecolum series and ciliates Tetrahymena pyriformis.
Treatment of NPMG with UV irradiation + ozonation leads to a 10-fold decrease
in toxicity. Using lux-biosensors based on Escherichia coli, the ability of
NPMG photochemical decomposition products to induce oxidative stress in
bacterial cells was studied. A comparative study of genetic effects using two
genetic bacterial test systems showed that among the products of NPMG
photochemical decomposition, there are substances with weak mutagenic and
genotoxic activity. It was shown that NPMG inhibits the activity of horseradish
root peroxidase by a competitive type: Ki = 0.1004 mM; Km = 1.776 mM; I50 =
0.302 mM. The obtained data show that NPMG is able to block the antioxidant
system and can cause the accumulation of free radicals in warm-blooded
organisms, which is an addition to the available literature data on the
biological targets of the Roundup herbicide.
Author(s) Details
Saratovskikh E. A.
Federal
Research Center of Problems of Chemical Physics and Medicinal Chemistry,
Russian Academy of Sciences, Chernogolovka, Russian Federation.
Please
see the book here:- https://doi.org/10.9734/bpi/cbrp/v7/5808
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