The present study described the characteristics of MSC-sEVs and
discussed their therapeutic potential in chronic wound treatment. Additionally,
the study also provided an overview of the application avenues of MSC-sEVs in
wound treatment. Chronic non-healing wounds have posed a severe threat to
patients mentally and physically. Dysregulation of behavior in the surviving
cells at the sites of wounds is known to be the key factor that destroys the
healing process and prevents wound healing. Therefore, the mainstay of treating
chronic non-healing wounds is controlling and reestablishing normal cellular
function. In recent years, the therapy
with mesenchymal stem cells (MSCs) has become a promising option for chronic
wound healing and the efficacy has increasingly been attributed to their
exocrine functions. Small extracellular vesicles derived from MSCs (MSC-sEVs)
are reported to benefit almost all stages of wound healing by regulating the
cellular behavior to participate in the process of inflammatory response,
angiogenesis, re-epithelization, and scarless healing. The study summarized
strategies for large-scale production and engineering of MSC-sEVs. This review
may possibly provide meaningful guidance for chronic wound treatment with
MSC-sEVs. Further research is still imperative to unveil the advantages and
disadvantages of the clinical application of MSC-sEVs on chronic nonhealing
wounds. After the above issues are resolved, it is believed that MSC-sEV
therapy is expected to be a potential and encouraging method for rapid and
complete regeneration of chronic non-healing wounds.
Author(s) Details
Qian
Wei
Research Center for Tissue Repair and Regeneration Affiliated to
the Medical Innovation Research Division and the 4th Medical Center of Chinese
PLA General Hospital, Beijing, 100048, China.
Xi Liu
Research Center for Tissue Repair and Regeneration Affiliated to
the Medical Innovation Research Division and the 4th Medical Center of Chinese
PLA General Hospital, Beijing, 100048, China.
Cui-Ping
Zhang
Research Center for Tissue Repair and Regeneration Affiliated to
the Medical Innovation Research Division and the 4th Medical Center of Chinese
PLA General Hospital, Beijing, 100048, China, Research Unit of Trauma Care,
Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, 2019RU051,
Beijing, 100048, China and PLA Key Laboratory of Tissue Repair and Regenerative
Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and
Regeneration, Beijing, 100048, China.
Zi-Qiang
Chu
Research Center for Tissue Repair and Regeneration Affiliated to
the Medical Innovation Research Division and the 4th Medical Center of Chinese
PLA General Hospital, Beijing, 100048, China.
Kui Ma
Research Center for Tissue Repair and Regeneration Affiliated to
the Medical Innovation Research Division and the 4th Medical Center of Chinese
PLA General Hospital, Beijing, 100048, China, Research Unit of Trauma Care,
Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, 2019RU051,
Beijing, 100048, China and PLA Key Laboratory of Tissue Repair and Regenerative
Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and
Regeneration, Beijing, 100048, China.
Qi-Lin
Huang
Research Center for Tissue Repair and Regeneration Affiliated to
the Medical Innovation Research Division and the 4th Medical Center of Chinese
PLA General Hospital, Beijing, 100048, China.
Hai-Hong
Li
Department of Wound Repair, Institute of Wound Repair and
Regeneration Medicine, Southern University of Science and Technology Hospital,
Southern University of Science and Technology School of Medicine, Shenzhen
518055, China.
Xiao-Bing
Fu
Research Center for Tissue Repair and Regeneration Affiliated to
the Medical Innovation Research Division and the 4th Medical Center of Chinese
PLA General Hospital, Beijing, 100048, China, Research Unit of Trauma Care,
Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, 2019RU051,
Beijing, 100048, China and PLA Key Laboratory of Tissue Repair and Regenerative
Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and
Regeneration, Beijing, 100048, China.
Cui-Ping
Zhang
Research Center for Tissue Repair and Regeneration Affiliated to
the Medical Innovation Research Division and the 4th Medical Center of Chinese
PLA General Hospital, Beijing, 100048, China, Research Unit of Trauma Care,
Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, 2019RU051,
Beijing, 100048, China and PLA Key Laboratory of Tissue Repair and Regenerative
Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and
Regeneration, Beijing, 100048, China.
Please
see the book here:- https://doi.org/10.9734/bpi/ibs/v9/1549
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