Genetic Study through Multiomics Technology and Use of DNA-adductomes to Know the Cause of Certain Diseases and Environmental Pollution | Chapter 2 | Current Advances in Plant Science, Molecular Biology and Health Sector

 

Multi‐omics usually refers to the crossover application of multiple high‐throughput screening technologies, which play a great role in promoting the study of human diseases. With the advancement of DNA sequencing technology, biological analysis is done using multiple omes such as Genome, Proteome, Transcriptome, Epigenome, Metabolome, etc.  Recently, another biological technique known as DNA Adductome has been used to detect the cause of DNA damage done by many chemical agents, drugs, pollutants, etc. Details of Next Generation Technology and Alignment technology have been discussed in this study. The application of Next Generation Sequencing (NGS) technology has been applied for the improvement of crop plants.

 

When DNA is bound to any chemical, it is called a DNA Adduct, and the discipline is called DNA –DNA-Adductomes.  The adduct formation leads to DNA damage resulting in mutation. The origin of many human diseases, like cancer and others, has been found to be due to the formation of DNA adducts. The study of DNA adducts has great potential in noting the carcinogenic effects of toxic chemicals, their mode of action and the damage caused by these chemicals, as well as to identify the marker. The way of adduct formation in DNA has been discussed with special reference to human health. The measurement and identification of environmental pollutants can be monitored through the study of DNA adducts. Thus, this multiomic technology, including DNA Adductomes, may bring a revolution in medicine and toxicological studies.

 

Author(s) Details

Professor Satyesh Chandra Roy
Department of Botany, Centre of Advanced Study for Cell and Chromosome Research, University of Calcutta, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-81-989371-7-9/CH2

Study on Genome Sequencing Practices as Driving Force of Clinical Research Modernization in the Future | Chapter 10 | Issues and Development in Health Research Vol. 3

 Genome sequencing is one of the most recent technologies to be incorporated into medical practises for disease diagnosis and medication development studies. It's frequently used in genomic medicine to process and analyse information about genes and markers in order to diagnose and cure disease. Genomic medicine, in particular, use DNA and RNA platform sequencing technologies to examine the human genome for mutations and molecular abnormalities with evident clinical implications that may be linked to uncommon genetic illnesses. With the help of these genomic sequencing platforms, the Human Genome Sequencing Project, which discovered roughly 35,000 genes in sequences of more than 3 billion human DNA and RNA chemical bases, was finished in 2003. (first- and second-generation sequencing technologies). This paved the path for genomic medicine, allowing researchers to undertake translational genomic clinical trials, which have improved the clinical trial process in a number of ways.

Author (S) Details

Yawo M. Akrodou
Department of Health Science, Walden University, USA.

View Book :- https://stm.bookpi.org/IDHR-V3/article/view/3304

An Advanced Review of Next Generation Sequencing in Oral Disease Diagnostics | Chapter 3 | Highlights on Medicine and Medical Science Vol. 10

 The procedure of determining the precise order of DNA nucleotides within a molecule is known as DNA sequencing. DNA sequencing knowledge is essential for basic biological research as well as a variety of clinical specialties. They can be used to sequence RNA and proteins, as well as determine individual genetic sequences, larger genetic areas, and chromosomes. There have been enormous improvements in technologies targeted at determining the full human genome since the initial DNA sequencing in the 1970s. The need for speedy and accurate human genome sequencing As a result, next-generation sequencing technology has been introduced. Next-generation sequencing refers to second-generation DNA sequencing technology that can sequence millions of DNA molecules at once. Roche/454 life science, Illumina/ Solexa, SOLiD system, and HeliScope are some of the next-generation sequencing technologies used. The use of next-generation sequencing to decode the genetic database of a variety of oral disorders could have therapeutic and predictive implications. The goal of this review is to give readers a deeper understanding of how next-generation sequencing can be used to diagnose oral diseases.

Author (S) Details

Dr. Sridharan Gokul
Department of Oral Pathology and Microbiology, Dr. G. D. Pol Foundation YMT Dental College and Hospital, Mumbai 410210, India.

View Book :- https://stm.bookpi.org/HMMS-V10/article/view/2251