Significance of Vitamin C in Cancer Prevention and Therapy: A Review |Chapter 9 | Disease and Health Research: New Insights Vol. 6

The relationship between vitamin C and cancer is still being studied and is associated with antioxidant, pro-oxidant, and gene expression regulator properties. Vitamin C is a water-soluble antioxidant associated with the prevention of the common cold and is also a cofactor of hydrolases that participate in the synthesis of collagen and catecholamines and in the regulation of gene expression. This review explores the role of vitamin C in cancer clinical trials and the aspects to consider in future studies, such as plasmatic vitamin C and metabolite excretion recording, and metabolism and transport of vitamin C into cancer cells. The reviewed studies show that vitamin C intake from natural sources can prevent the development of pulmonary and breast cancer and that vitamin C synergizes with gemcitabine and erlotinib in pancreatic cancer. Vitamin C homeostasis is controlled mainly by four regulatory processes: (i) intestinal absorption (bioavailability), (ii) accumulation and distribution in tissues, (iii) utilization and recycling, and (iv) renal excretion and reabsorption. In vitro assays reveal that vitamin C synergizes with DNA-methyl transferase inhibitors. However, vitamin C was not associated with cancer prevention in a Mendelian randomized study. The effects of vitamin C on cancer progression depend on the route of administration. It is concluded that the role of vitamin C in the prevention and treatment of cancer is still an ongoing area of research. It is necessary that new phase II and III clinical trials be performed to collect stronger evidence of the therapeutic role of vitamin C in cancer.  Clinical trials with Intravenous Ascorbic Acid as a co-adjuvant in radiotherapy or chemotherapies with gemcitabine, erlotinib, and DNA Methyltransferases inhibitors are assays in development with promising results. It is expected that new studies will reveal more about the mechanisms of the anti-cancer action of vitamin C, with new, well-structured phase II and III clinical trials performed to confirm its proposed beneficial effect on cancer prevention and treatment.

 

Author (s) Details

Lorena Mardones
Biomedical Sciences Research Laboratory, Faculty of Medicine, Universidad Catolica de la Santisima Concepcion, Concepcion 4070129, Chile and Research Center on Biodiversity and Sustainable Environments (CIBAS), Universidad Catolica de la Santisima Concepcion, Concepcion 4070129, Chile.

 

 

Please see the book here:- https://doi.org/10.9734/bpi/dhrni/v6/1745

 

Gene Therapy: Examining the Current Progress | Chapter 3 | Achievements and Challenges of Medicine and Medical Science Vol. 9

In the past few years, the genetic field has achieved a fast pace in clinical research and trials. The research and various studies have indicated the future of human genotype to emerge as the new genetic world from the present nascent one. Gene therapy is the replacement of a defective gene with a normal gene constituent. Several methods for this have emerged and many more are evolving. Genetic involvement in the association of life on earth was found more than a century ago, but its implication in the medical field has been possible just a few years earlier. Still, gene therapy is in its very nascent stage and various experiments are going on. Availability of gene therapy for mass population with feasibility and safety can be made by the medical fraternity keeping patients till the time when research and trials in the genetic field will approve for it. This review will help in understanding the recent gene therapy trials which indicate the forthcoming era of the human genome and their applicability in overcoming the hurdles in treatments of various genetic disorders. The study concluded that gene therapy is not only helpful for the treatment of genetic disorders but also as an adjuvant for other regimens like chemotherapy for cancers etc. Therefore, a close watch on ongoing research and trials in the genetic field in search of better options for treating various disorders in human beings is necessary.

 

Author (s) Details

 

Sachin Phoolchand Yadav
Department of Anatomy, Grant Govt. Medical College and Sir J.J. Group of Hospitals, Mumbai- 400008, Maharashtra, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/acmms/v9/3396

Artificial Intelligence (AI) and Its Application in Pharmacy | Chapter 12 | Advances and Challenges in Science and Technology Vol. 9

 The AI is an active tool for data excavating based on the gigantic pharmacological data and machine learning process. Therefore, AI has been used in again drug design, activity scoring, in essence screening and in silico judgment in the properties (absorption, classification, metabolism, excretion and toxicity) of a drug particle. AI has made important contributions to the healthcare industry in any of areas, including the administration and storage of data and news about patient medical histories, cure stocks, sale records, and more; automated appliance; software and computer uses; and diagnostic finishes like CT and MRI diagnostics. All of these have been grown to support and streamline healthcare procedures. As expected, artificial intelligence (AI) has transformed healthcare expected more effective and adept, and the pharmaceutical industry is not exempt. All along the past few years, a substantial amount of increasing interest in the uses of AI science has been identified for resolving as well as interpreting few important fields of pharmacy like drug finding, dosage form crafty, poly pharmacology, and hospital pharmacy. AI-located solutions have been labeled which involve platforms that can make use of a difference of data types viz. manifestations reported for one patients, biometrics, imaging, biomarkers, etc. We engaged to produce a thorough report that would aid every undertaking pharmacist in understanding the major progresses made likely by the application of machine intelligence (AI), in light of the field's expanding meaning. In order to conclude the outbreaks of COVID-19, Zika, Ebola, and seasonal influenza, deep education and neural networks were utilized. Accompanying the advancement of AI technologies, the experimental community concede possibility witness rapid and cost-effective healthcare and drug research as well as provide upgraded service to the society.

Author(s) Details:

R. Radha,
Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy (Autonomous), Tirupati, India.

V. Neelima,
Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy (Autonomous), Tirupati, India.

M. P. VedaVarshan,
Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy (Autonomous), Tirupati, India.

S. Saqib Basha,
Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy (Autonomous), Tirupati, India.

U. Jeevitha,
Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy (Autonomous), Tirupati, India.

M. A. KapilKumar,
Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy (Autonomous), Tirupati, India.

G. Sateesh Kumar,
Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy (Autonomous), Tirupati, India.

Please see the link here: https://stm.bookpi.org/ACST-V9/article/view/12634

Immunomodulatory Effects of Herbal Formulation Post Covid 19 Vaccination | Chapter 10 | New Advances in Medicine and Medical Science Vol. 9

 This affiliate aims to evaluate the immunogenicity increase (specific basic immune answers (CD3+, CD4+, and CD8+) of a herbal formulation in COVID-19-immunized subjects the one received two doses of Covaxin.Traditional herbal cures, which stress a holistic, patient-centric view of ailment treatment, supply an exciting starting point for finding of new immunomodulatory drugs. Progress on identification of herbaceous molecules with confirmed single power activity has been slow, incompletely because of lacking consideration of pharmacology fundamentals. The trial design was a double-blind&fake pill-controlled, randomised, parallel-group authentication-of-concept study to evaluate the security & immunogenicity of a herbal readiness in healthy subjects of Indian inception who have taken the COVID-19 vaccination (Covaxin). For independent samples, the t-test aided compare mean biomarker principles between two groups, while the paired t-test assisted compare flag values in follow-boosts. At day 28, the mean (lines) concentration of IgG antibodies in the test group was substantially more in the placebo group (p=0.04). Although the aggregation of the marker reduced significantly in the placebo group (p = 0.021), it stopped virtually constant in the test group (p = 0.824). Importance of herbaceous intervention embellishes the immunity (antibodies)following vaccine is a very main finding in this place proof-of-concept study. Otherwise in immunized person the privilege reduces significantly over a period of time, that necessities additional dose of vaccine at certain intervals. The present study is a effect to the earlier search and confirmed our findings in colleagues who had taken two doses of Covaxin. To verify our findings, this unmistakably has to be intentional in a wider population. According to our article search, this kind of study has not happened done before. This investigation raise no adverse reactions, confirming the safety of the expression and the herbal immunization.

Author(s) Details:

Suresh B. Patankar,
Ace Hospital and Research Center Pune, Maharashtra, India, Shripad Medisearch Pvt. Ltd., Pune, Maharashtra, India and ATRC Dept. Ace Hospital, Pune, Maharashtra, India.

Anupama Gorde,
Ace Hospital and Research Center Pune, Maharashtra, India and Sinhgad Institute of Medical Sciences, Pune, Maharashtra, India.

Sagar Patankar,
Ace Hospital and Research Center Pune, Maharashtra, India and Shripad Medisearch Pvt. Ltd., Pune, Maharashtra, India.

Rajesh Raje,
Ace Hospital and Research Center Pune, Maharashtra, India.

Chadrashekhar Gillurkar,
Gillurkar Multispeciality Hospital and Research Centre, Nagpur, Maharashtra, India.

Pranjal Ausekar,
Ardent Clinical Research Pvt. Ltd., Pune, Maharashtra, India.

Gaurav Patil,
Ardent Clinical Research Pvt. Ltd., Pune, Maharashtra, India.

Please see the link here: https://stm.bookpi.org/NAMMS-V9/article/view/11260

Post COVID Syndrome or Long COVID: An Overview| Chapter 2 | Current Overview on Disease and Health Research Vol. 6

 The all-encompassing pandemic began by the SARS-CoV-2 virus has damaged every chaste worldwide. The novelty concerning this virus, allure mutations and the rapid speed and exceptional rate at which it has torn through the worldwide community has in proper sequence lead to an innate ignorance and information about the real disease provoked and the severity of the complications guide COVID-19. The SARS-CoV-2 virus has happened infecting individuals because 2019 and now as of 2022 has existed circulating for just over 2 years inside the global various. As the number of cases have risen everywhere over this period (some of that having weakened the virus twice) further endeavours have happened undertaken to better think the pathogenesis and natural progress of the disease. A condition reported in few cases with comprehensive bouts of sickness or syndromes following the initial contamination with COVID was described “long COVID” towards the earlier phases of the universal (in the spring of 2020), but has only recently win the global media and healing attention on account of its disorder of more individuals on a global base and has thus authorized further investigation.It is clearly apparent that a substantial scarcity in information encircling the SARS-CoV-2 virus and its unending effects lies, as a substantial rise in post COVID symptoms and confusions have been stated globally.  The objective concerning this research was to find out the signs and syndromes, treatment, arising therapies and ongoing dispassionate trials of Long COVID.Long COVID is named as a persistent, long-term state of disability following an infection accompanying COVID-19. The effect of Long COVID is multisystemic in nature accompanying a wide array of signs and symptoms. The most usually reported dispassionate features of long COVID are: headaches, myalgia, chest pain, rashes, intestinal pain, shortness of whiff, palpitations, anosmia, persistent cough, intelligence fogs, forgetfulness, depression, restlessness, fatigue and anxiety. Currently no authoritative treatment against Long COVID has been certified and the mainstay situation is divided into Symptomatic, Supportive and Rehabilitative situation with self-monitoring. The bottom line of the current treatment flows for Long COVID is that of a multidisciplinary approach with a excellent portion of the treatment implicating the patient to take an alive role in their improvement, self-monitoring and treatment of the condition. Hyperbaric oxygen therapy (HBOT), Vitamin C as well as the use of adaptogens has proved promising results and is advisable expected added to the situation regimen of cases to aid in decreasing fatigue in patients pain from post-COVID syndrome. The use of melatonin in cases suffering from insomnia and weak sleep hygiene is likewise advisable. Currently numerous pharmacotherapeutic powers ranging from Montelukast, Deupirfenidone, Nicotinamide riboside, Leronlimab, Adaptogens, Tocilizumab, Probiotics to HBOT are withstanding clinical tests. It is thus with promising expectancy that these drug troubles will yield a viable definitive situation for Long COVID.

Author(s) Details:

Indrajit Banerjee,
Department of Pharmacology, Sir Seewoosagur Ramgoolam Medical College, Belle Rive, Mauritius.

Jared Robinson,
Sir Seewoosagur Ramgoolam Medical College, Belle Rive, Vacoas-Phoenix, Mauritius.

Please see the link here: https://stm.bookpi.org/CODHR-V6/article/view/8598

Study on Genome Sequencing Practices as Driving Force of Clinical Research Modernization in the Future | Chapter 10 | Issues and Development in Health Research Vol. 3

 Genome sequencing is one of the most recent technologies to be incorporated into medical practises for disease diagnosis and medication development studies. It's frequently used in genomic medicine to process and analyse information about genes and markers in order to diagnose and cure disease. Genomic medicine, in particular, use DNA and RNA platform sequencing technologies to examine the human genome for mutations and molecular abnormalities with evident clinical implications that may be linked to uncommon genetic illnesses. With the help of these genomic sequencing platforms, the Human Genome Sequencing Project, which discovered roughly 35,000 genes in sequences of more than 3 billion human DNA and RNA chemical bases, was finished in 2003. (first- and second-generation sequencing technologies). This paved the path for genomic medicine, allowing researchers to undertake translational genomic clinical trials, which have improved the clinical trial process in a number of ways.

Author (S) Details

Yawo M. Akrodou
Department of Health Science, Walden University, USA.

View Book :- https://stm.bookpi.org/IDHR-V3/article/view/3304

NRCT Clinical Study in to Identify Acetaminophen-Induced Liver Injury Mechanism | Chapter 5 | Issues and Development in Health Research Vol. 3

 Acetaminophen (APAP) (N-acetyl-p-aminophenol) is a chemical compound utilised in paracetamol treatments to reduce pain and lower fever. In June 2009, an FDA advisory group issued a warning concerning the potential of APAP overdose due to the drug's side effects, which include drug-induced liver damage. In addition, the FDA has begun collecting data on APAP toxicity biomarkers in children and adolescents through multicenter non-interventional case-control studies. The National Center for Toxicological Research is a non-profit organisation that does toxicological research (NCTR), In partnership with various health institutes (hospitals, universities, and clinical centres) around the United States, the FDA coordinates the execution of APAP clinical trials. The purpose of these clinical trials is to collect enough data to build a list of biomarkers linked to acetaminophen toxicity that can be matched with specific adduct proteins; this information can then be used to investigate and predict future risks in children who are taking acetaminophen.

Author (S) Details

Yawo Akrodou
Department of Health Science, Walden University, Minneapolis, USA.

View Book :- https://stm.bookpi.org/IDHR-V3/article/view/3299

India’s New Drugs and Clinical Trial Rules: Perception and Perspectives of Indian Researchers | Book Publisher International

 Background/Purpose: Few studies have examined investigators' and ethics members' understanding of previous guidelines, as well as their perspectives on them. No study, however, has looked into the perceptions and viewpoints of Indian researchers on the most recent medications and clinical trial regulations for 2019. (NDCTR-19). The current study's goal is to find a solution to this problem.

Methods: The Checklist for Reporting Results of Internet E-Surveys was used to create a web-based online survey using a widely approved Google form with an already verified questionnaire. Participants were given a web URL to use in order to respond to the survey. Between July and September 2019, the data was gathered by emailing the link to several researchers across India. The perceptions and viewpoints of Indian scholars were expressed as a percentage (%) and a mean (%). (standard deviations).

The NDCTR-19 was perceived by 75 (70.8 percent) of the 106 researchers, including those from all zones (100 percent, p.0001). Changes to the timeframe, open post-trial drug passage, and embracing equality were all approved by 36 (63.2%), 32 (53.1%), and 31 (54.5%) of respondents, respectively. 37 people agreed that recent developments in severe adverse effects and compensation were beneficial (64.9 percent ). Furthermore, the majority of respondents felt that sharing the NDCTR-19 with other researchers, particularly those from the central zone, would impact the working atmosphere (100 percent, p.0001, respectively).

Conclusion: The findings suggest that the NDCTR-19 can help speed up clinical trials and expand India's pharmaceutical sector. The findings will be of interest to investigators as well as stakeholders from pharmaceutical corporations on a national and worldwide level.

Author(S) Details

Vishal Vennu
School of Pharmacy, Lingaya’s Vidyapeeth, Faridabad, India and Department of Rehabilitation Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.

View Book:- https://stm.bookpi.org/INDCTRPPIR/article/view/3787

Clinically Oriented Pharmacology Exercises and Innovative Evaluation System | Chapter 4 | Technological Innovation in Pharmaceutical Research Vol. 11

 Medical science is a large topic that deals with human life; as a result, talents, communication, and decision-making abilities are critical components of medical knowledge. Students are under pressure from all sides of society in today's modern world. During college, common concerns include financial strain, a hostile environment, senior and peer group pressure, single parents, drug addiction, and love affairs. Job insecurity after graduation will cause financial anxiety in the future. Pharmacology is an important field of medicine with a lot of therapeutic applications. Pharmacology is the study of prescriptions and pharmacotherapy in any clinical area. This is due to the fact that we are always attached to our ancient tradition, yet times have changed and the old presentation needs to be updated. This chapter discussed some of the more advanced and inventive approaches to practical, written, and oral examinations.

Author (S) Details

Rakesh Chandra Chaurasia
Department of Pharmacology, M.L.N. Medical College, Allahabad 211002, India.

View Book :- https://stm.bookpi.org/TIPR-V11/article/view/3126

Studies on Development of New Method for the Prediction of Clinical Trial Results Using Compressive Sensing of Artificial Intelligence | Chapter 9 | Theory and Practice of Mathematics and Computer Science Vol.2

 

We applied the compressive sensing in this analysis to an observational sample of clinical trials consisting of two groups. Each group needed time data from 25 patients, but in order to accommodate alpha and beta errors, data from 12 more patients had to be acquired. Thus, the unknown knowledge was predicted using the process of compressive sensing. For each one, the calculation was repeated 1,000 times, and 1 million (= 1,0002) log-rank tests were performed between the two classes, after which a P-value histogram was obtained. Information obtained by repeated estimates on the distribution of expected data represents the likelihood of statistical significance. This technique will be   It is useful for clinical trials studying rare diseases or if the registration process is delayed.

Author (s) Details

Y. Miyagi
Department of Gynecology, Miyake Ofuku Clinic, Okayama City, Japan and Department of Artificial Intelligence, Medical Data Labo, Okayama City, Japan.

K. Fujiwara
Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka City, Japan.

T. Oda
Department of Obstetrics and Gynecology, Miyake Clinic, Okayama City, Japan.

T. Miyake
Department of Gynecology, Miyake Ofuku Clinic, Okayama City, Japan. and Department of Obstetrics and Gynecology, Miyake Clinic, Okayama City, Japan.

R. L. Coleman
Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/271