Aim: The present work was designed to evaluate the anti-inflammatory properties of Asparagus officinalis (AO) extract on liver inflammation CGN-induced.
Background: Inflammation itself results in more hepatic cell
damage, and a flow of cytokines and chemokines called inflammatory mediators is
released, which in turn leads to the accumulation of leukocytes, mast cells, and
macrophages in the inflammation site.
Materials and Methods: Forty male Swiss albino mice were divided
randomly into four groups, 10/each. The first group acted as untreated control,
the second group was treated daily with an oral dose of (500 mg/kg) AO extract
for one week, the third group was treated with a single dose of 2%W/V
carrageenan (CGN) intraperitoneally, and left for one week, the fourth group
treated with carrageenan as a third group and AO extract as the second group.
Results: CGN injection resulted in a significant increase of WBCs
and platelets, elevation of liver enzymes, and proinflammatory cytokines (TNF- α and IL6). Morphological features
of the tails showed severe necrosis, and histopathological examination of tail
tissue displayed a heavy incidence of inflammatory cells in the dermis layer
and liver revealing severe inflammation, steatosis, and ballooning. The present
study showed that a single dose of carrageenan could induce severe hepatic
inflammation represented by an increase in liver enzyme activities (ALT, AST,
and ALP) which due to hepatocellular degeneration leads to the draining of
enzymes in the bloodstream. Several studies declared that AO extracts improved
the elevated liver enzymes by bisphenol A. Meanwhile, post-treatment with AO
extract after CGN showed a significant decrease in WBCs, platelets, and
physiological parameters. Histopathological analysis revealed less incidence of
inflammation in the tail and liver tissue besides improvement of tissues and
pathological score.
Conclusion: Post-treatment with AO extract after CGN injection
showed significant improvement manifested by lowering liver enzymes, cytokines,
and liver inflammation.
Author(s)
Details
Doaa M.
Elnagar
Zoology Department, Faculty of Women for Arts, Science and
Education, Ain Shams University, Egypt and Zoology Department, College of
Science, King Saud University, Saudi Arabia.
Please see the book here:- https://doi.org/10.9734/bpi/ibs/v10/1975
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