Aims: This study aims to evaluate the effects of customized
zirconia barrier membranes produced for guided bone regeneration approaches on
bone healing researched with histological and histomorphometric methods.
Study Design: In vivo experimental study.
Place and Duration of Study: The digital modeling and
writing phase took place at Istanbul University Faculty of Dentistry,
Department of Oral Implantology. The surgeries and sacrification procedures for
the experimental animals were carried out in the operating rooms of the Surgery
Department at the Faculty of Veterinary Medicine, Bursa Uludag University. The
bone tissue samples obtained were histologically and histomorphometrically
evaluated in the laboratories of the Pathology Department at the same university.
The study started in August 2022 and ended in February 2024.
Methodology: The research involved using digital modeling to
create zirconia barrier membranes suitable for a defect in the tibia bone.
These membranes were designed using a 3D software system and transferred to the
CAD/CAM software system in STL format. Zirconia discs (1400 Mpa) (Aconia BSM-
D98x16, HT+, Germany) were then milled and sintered. The defects were covered
using titanium mesh, titanium-reinforced d-PTFE, and zirconia barrier membranes,
while one defect was left empty for the control group. At 3 and 6 weeks into
the healing period, samples were obtained from each group after sacrificing the
animals. Histomorphometric and histological analyses were conducted to evaluate
new bone formation, the amount of remaining grafts, and tissue response
parameters.
Results: The newly formed bone amounts of the zirconia
barrier membrane, titanium membrane, and d-PTFE membrane groups were
significantly higher than the control group in the 3rd and 6th weeks. The
amount of residual graft progressed at a low level in both periods without any
difference in the other groups except the control group. No foreign body
reaction or necrosis was observed in any of the defects.
Conclusion: With the limitation of the study, it has been
concluded that effective results can be obtained with zirconia barrier
membranes in GBR procedures.
Author (s) Details
Zeynep Tuncludemir
Institute of Graduate Studies in Health Sciences, Oral Implantology
Program, Istanbul University, Istanbul, Turkiye.
Please see the book here:- https://doi.org/10.9734/bpi/mmrnp/v7/2347
No comments:
Post a Comment