Comparative Evaluation of GBR Techniques Using Zirconia Barrier Membrane: An In-vivo Study | Chapter 5 | Medicine and Medical Research: New Perspectives Vol. 7

 

Aims: This study aims to evaluate the effects of customized zirconia barrier membranes produced for guided bone regeneration approaches on bone healing researched with histological and histomorphometric methods.

 

Study Design: In vivo experimental study.

 

Place and Duration of Study: The digital modeling and writing phase took place at Istanbul University Faculty of Dentistry, Department of Oral Implantology. The surgeries and sacrification procedures for the experimental animals were carried out in the operating rooms of the Surgery Department at the Faculty of Veterinary Medicine, Bursa Uludag University. The bone tissue samples obtained were histologically and histomorphometrically evaluated in the laboratories of the Pathology Department at the same university. The study started in August 2022 and ended in February 2024.

 

Methodology: The research involved using digital modeling to create zirconia barrier membranes suitable for a defect in the tibia bone. These membranes were designed using a 3D software system and transferred to the CAD/CAM software system in STL format. Zirconia discs (1400 Mpa) (Aconia BSM- D98x16, HT+, Germany) were then milled and sintered. The defects were covered using titanium mesh, titanium-reinforced d-PTFE, and zirconia barrier membranes, while one defect was left empty for the control group. At 3 and 6 weeks into the healing period, samples were obtained from each group after sacrificing the animals. Histomorphometric and histological analyses were conducted to evaluate new bone formation, the amount of remaining grafts, and tissue response parameters.

 

Results: The newly formed bone amounts of the zirconia barrier membrane, titanium membrane, and d-PTFE membrane groups were significantly higher than the control group in the 3rd and 6th weeks. The amount of residual graft progressed at a low level in both periods without any difference in the other groups except the control group. No foreign body reaction or necrosis was observed in any of the defects.

 

Conclusion: With the limitation of the study, it has been concluded that effective results can be obtained with zirconia barrier membranes in GBR procedures.

 

Author (s) Details

 Zeynep Tuncludemir
Institute of Graduate Studies in Health Sciences, Oral Implantology Program, Istanbul University, Istanbul, Turkiye.

 

Please see the book here:- https://doi.org/10.9734/bpi/mmrnp/v7/2347

Transcriptomic Overview of Comparative Multi-Scale Biocompatibility of ZrO2 and Y-TZP Alloys | Chapter 2 | Chemical and Materials Sciences - Developments and Innovations Vol. 2

 

The present study assesses the biocompatibility of pure zirconia discs ZrO₂ compared to yttria–zirconia discs (Y-TZP) as well as the influence of the surface topography through the combination of a conventional toxicological assay, morphological observations, and a transcriptomic analysis on an in vitro model of human Saos-2 bone cells. The direct anatomical and functional bond between the surface of an implant and living neoformed bone is known as the osseointegration of implants. Implants' biological compatibility is contingent upon a number of factors, including surface topography, chemical composition, material type, and mechanobiological characteristics. Similar cell proliferation rates were observed between ZrO₂ and Y-TZP discs and control cells, independent of surface topography, for up to 96 hours of exposure. High cell density was similarly observed on the surfaces of both materials. It could be interesting to perform a comparative transcriptomic study between rough and mirror-polished Y-TZP samples to observe a potential influence of the surface topography on the gene expression and to better understand the underlying mechanisms. Relevantly, only 110 transcripts were differentially expressed across the human transcriptome, consistent with the excellent biocompatibility of Y-TZP reported in the literature. These deregulated transcripts are mainly involved in two known metabolic pathways, the first being linked to 'mineral absorption' and the second to 'immune response'. These observations suggest that Y-TZP is an interesting candidate for application in implantology. Y-TZP is a serious candidate for implantology in general. However, further biocompatibility and biomechanical studies are needed to position Y-TZP as a reference material in oral implantology and to find the best roughness level for this material.

 

Author(s)details:-

 

Alex Tchinda
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

 

Laëtitia Chézeau
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

 

Gaël Pierson
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

 

Richard Kouitat-Njiwa
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

 

B. H. Rihn
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

Pierre Bravetti
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

 

Please See the book here :-  https://doi.org/10.9734/bpi/cmsdi/v2/12008F

A Detailed and Comparative Study on Conventional Sintering with Microwave Sintering and Vacuum Sintering of Y2O3-Al2O3-ZrO2 Ceramics | Chapter 12 | Current Perspectives on Chemical Sciences Vol. 6

 This chapter focused on comparative studies on conventional, microwave and vacuum sintering of alumina-added stabilised zirconia yttria (YSZ). When energy and time savings are involved, microwave sintering has been found to be the most effective sintering technique. In contrast to the conventionally sintered ones, microwave and vacuum sintered specimens display improved densification at lower temperatures. In contrast to the traditional and vacuum sintered specimens, the microwave sintered specimen displayed the highest hardness. In addition, it was found that the size of the particle had a prominent role in regulating densification enhancement.

Author(s) Details

Mayur Shukla
Academy of Scientific and Innovative Research (AcSIR), CSIR-Central Glass and Ceramic Research Institute, Kolkata, India and CSIR-Central Glass and Ceramic Research Institute (CSIR-CGCRI), Kolkata, India.

Sumana Ghosh
CSIR-Central Glass and Ceramic Research Institute (CSIR-CGCRI), Kolkata, India.

Nandadulal Dandapat
CSIR-Central Glass and Ceramic Research Institute (CSIR-CGCRI), Kolkata, India.

Ashis K. Mandal
CSIR-Central Glass and Ceramic Research Institute (CSIR-CGCRI), Kolkata, India.

Vamsi K. Balla
CSIR-Central Glass and Ceramic Research Institute (CSIR-CGCRI), Kolkata, India.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/355