Transcriptomic Overview of Comparative Multi-Scale Biocompatibility of ZrO2 and Y-TZP Alloys | Chapter 2 | Chemical and Materials Sciences - Developments and Innovations Vol. 2

 

The present study assesses the biocompatibility of pure zirconia discs ZrO₂ compared to yttria–zirconia discs (Y-TZP) as well as the influence of the surface topography through the combination of a conventional toxicological assay, morphological observations, and a transcriptomic analysis on an in vitro model of human Saos-2 bone cells. The direct anatomical and functional bond between the surface of an implant and living neoformed bone is known as the osseointegration of implants. Implants' biological compatibility is contingent upon a number of factors, including surface topography, chemical composition, material type, and mechanobiological characteristics. Similar cell proliferation rates were observed between ZrO₂ and Y-TZP discs and control cells, independent of surface topography, for up to 96 hours of exposure. High cell density was similarly observed on the surfaces of both materials. It could be interesting to perform a comparative transcriptomic study between rough and mirror-polished Y-TZP samples to observe a potential influence of the surface topography on the gene expression and to better understand the underlying mechanisms. Relevantly, only 110 transcripts were differentially expressed across the human transcriptome, consistent with the excellent biocompatibility of Y-TZP reported in the literature. These deregulated transcripts are mainly involved in two known metabolic pathways, the first being linked to 'mineral absorption' and the second to 'immune response'. These observations suggest that Y-TZP is an interesting candidate for application in implantology. Y-TZP is a serious candidate for implantology in general. However, further biocompatibility and biomechanical studies are needed to position Y-TZP as a reference material in oral implantology and to find the best roughness level for this material.

 

Author(s)details:-

 

Alex Tchinda
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

 

Laëtitia Chézeau
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

 

Gaël Pierson
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

 

Richard Kouitat-Njiwa
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

 

B. H. Rihn
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

Pierre Bravetti
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

 

Please See the book here :-  https://doi.org/10.9734/bpi/cmsdi/v2/12008F

Investigation of a New Ti Alloy for a New Generation of Additively Manufactured Implants with Lattice | Chapter 2 | Contemporary Perspective on Science, Technology and Research Vol. 7

 A new titanium alloy improving the operation of implants additively manufactured and including laterally closed lattice structures is proposed. The new alloy possesses an increased affinity to the bone. The measured bone–interface implant (BII) of less than 10 mm and bone–implant contact (BIC) of 95% demonstrated an excellent osseointegration. Furthermore, since additive manufacturing naturally leads to a high-roughness surface finish, the wettability of the implant is increased. The combination of these factors is pushing ossification beyond its natural limits. In addition, the quality and speed of the ossification and osseointegration in/around laterally closed lattice implants open the possibility of bone spline key of prostheses. This enables the stabilization of the implant into the bone while keeping the possibility of punctual hooks allowing the implant to be removed more easily if required.

Author(s) Details:

Anne-Françoise Obaton,
Laboratoire National de Métrologie et d’Essais (LNE), 75015 Paris, France.

Jacques Fain,
Z3DLAB, 95270 Chaumontel, France.

Dietmar Meinel,
8.5-Micro-NDT, Bundesanstalt für Materialforschung Und-Prüfung (BAM), 12205 Berlin, Germany.

Athanasios Tsamos,
8.5-Micro-NDT, Bundesanstalt für Materialforschung Und-Prüfung (BAM), 12205 Berlin, Germany.

Fabien Léonard,
8.5-Micro-NDT, Bundesanstalt für Materialforschung Und-Prüfung (BAM), 12205 Berlin, Germany.

Benoît Lécuelle,
Centre de Recherche Biomédicale, Ecole Nationale Vétérinaire d’Alfort, 94700 Maisons-Alfort, France.

Madjid Djemaï,
Z3DLAB, 95270 Chaumontel, France.

Giovanni Bruno,
8.5-Micro-NDT, Bundesanstalt für Materialforschung Und-Prüfung (BAM), 12205 Berlin, Germany.

Please see the link here: https://stm.bookpi.org/CPSTR-V7/article/view/13739

Ligaplants: The Next Generation of Dental Implants| Chapter 4 | Perspective of Recent Advances in Medical Research Vol. 2

 A fabric-engineered periodontal ligament (PDL) about implants can be secondhand as an important tool for substituting the absent natural dentition. The PDL is the key to tooth anchoring as it links tooth root and alveolar cartilage and it sustains bone composition. The most widely used implants in the current scenario are the osseointegrated implants accompanying various deficiencies and the most prominent individual lack periodontal ligament. The fields of fabric engineering and regenerative dentistry have sustained various progresses, yet its request to the field of implant dentistry is inadequate. The coming of periodontal tissue architecture has revolutionized field of prosthodontic implant dentistry. A critical new therapeutic procedure for replacing lost dentition is the development of the periodontal bond (PDL) attachment around dentures. Numerous essential cells that are crucial to the vital connection middle from two points the tooth and bone are protect in the PDL. In order to enhance organic function and lengthen the life of the dental prosthetic device, ligaplants are now a reasonable choice.

Author(s) Details:

Sylvana Achammada,
Department of Prosthodontics, Crown and Bridges, Sree Anjaneya Institute of Dental Sciences, India.

Please see the link here: https://stm.bookpi.org/PRAMR-V2/article/view/9012

Enhancement of Osseointegration of Bio-Active Material Surface by the Low-Intensive Pulsed Ultrasound Waving (LIPUS) | Chapter 13 | Recent Developments in Medicine and Medical Research Vol. 9

 For the stability of dental implants and artificial joints, excellent solid bonding between biomaterials and bone tissue (osseointegration and osteo-conductivity) is critical. Much has been learnt about this notion, leading to substantial advances in implant design and surface modification in the fields of implant dentistry and orthopaedic surgery.

We studied whether low-intensity pulsed ultrasound (LIPUS) could accelerate the osseointegration ability of bioactive materials such as bioactive titanium and hydroxyapatite for this issue.

Bio-active pure titanium and hydroxyapatite (HA) were used as materials, and an in vitro simulation test and an animal experiment were conducted.

The production of bone-like hydroxyapatite on the material surface in simulated body fluid (SBF) under LIPUS was evaluated in a simulation test. The bio-active samples implanted to the rabbits' femurs, which underwent LIPUS irradiation, were studied using Scanning Electron Microscope (SEM), X-ray diffraction (XRD), and histological observation in an animal test.

As a result of the crystal growth of bone-like apatite on the surface of the sample materials, LIPUS irradiation showed excellent enhancement of bone-material attachment, implying that LIPUS application has clinical potential to improve osseointegration (osteointegration), bone-bonding ability of bio-active materials.

Author(S) Details

Masanori Kobayashi
Department of Physical Therapy, College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai-City, Aichi, 487-8501, Japan.

View Book:- https://stm.bookpi.org/RDMMR-V9/article/view/4594