Transcriptomic Overview of Comparative Multi-Scale Biocompatibility of ZrO2 and Y-TZP Alloys | Chapter 2 | Chemical and Materials Sciences - Developments and Innovations Vol. 2

 

The present study assesses the biocompatibility of pure zirconia discs ZrO₂ compared to yttria–zirconia discs (Y-TZP) as well as the influence of the surface topography through the combination of a conventional toxicological assay, morphological observations, and a transcriptomic analysis on an in vitro model of human Saos-2 bone cells. The direct anatomical and functional bond between the surface of an implant and living neoformed bone is known as the osseointegration of implants. Implants' biological compatibility is contingent upon a number of factors, including surface topography, chemical composition, material type, and mechanobiological characteristics. Similar cell proliferation rates were observed between ZrO₂ and Y-TZP discs and control cells, independent of surface topography, for up to 96 hours of exposure. High cell density was similarly observed on the surfaces of both materials. It could be interesting to perform a comparative transcriptomic study between rough and mirror-polished Y-TZP samples to observe a potential influence of the surface topography on the gene expression and to better understand the underlying mechanisms. Relevantly, only 110 transcripts were differentially expressed across the human transcriptome, consistent with the excellent biocompatibility of Y-TZP reported in the literature. These deregulated transcripts are mainly involved in two known metabolic pathways, the first being linked to 'mineral absorption' and the second to 'immune response'. These observations suggest that Y-TZP is an interesting candidate for application in implantology. Y-TZP is a serious candidate for implantology in general. However, further biocompatibility and biomechanical studies are needed to position Y-TZP as a reference material in oral implantology and to find the best roughness level for this material.

 

Author(s)details:-

 

Alex Tchinda
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

 

Laëtitia Chézeau
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

 

Gaël Pierson
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

 

Richard Kouitat-Njiwa
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

 

B. H. Rihn
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

Pierre Bravetti
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy, France.

 

Please See the book here :-  https://doi.org/10.9734/bpi/cmsdi/v2/12008F

Optimization of Wear Behavior in Al-6061-B4C Composites Using Taguchi Technique and Response Surface Analysis | Chapter 2 | Current Innovations in Chemical and Materials Sciences Vol. 9

 

Metal Matrix Composites (MMCs) have been widely investigated and used in automobile and aerospace industries due to their advantages of improved strength, stiffness and increased wear resistance over monolithic alloys. Also considering limited reports on the study of weight % influence on wear characteristics of Al-6061-Boron Carbide (B4Cp) composites. This study presents the effect of weight % of B4Cp in Al-6061 alloy matrix on wear loss during dry sliding wear in pin-on-disc tribometer at different wear parameters against oil-hardened non-shrinking (OHNS) steel disk at room temperature. The composites are prepared by the stir casting technique. Taguchi is a statistical tool for acquiring data in a controlled way and is used to analyze the influence of process variables through the design of experimentation. Tribological investigations were examined according to the L9 orthogonal array of Taguchi. The influence of % of reinforcement along with load, speed and distance were examined for the wear loss of composites. The results, analysed using Taguchi and Response Surface Method to understand the significance of considered parameters (percentage of reinforcement, speed, time and load) on wear loss, revealed increased wear resistance of composite with increasing B4C particles. The observed results have been explained based on the microstructural behaviour and response surface of wear-tested composites. The study concludes that it is possible to prepare Al 6061-B4C composites using the stir casting technique, which exhibits improved hardness, wear resistance, and tensile strength with increasing reinforcement content.

Author(s) Details:

Dr. B. Manjunatha,
Department of Mechanical Engineering, Acharya Institute of Technology, Soldevanahalli, Hesaraghatta Main Road, Bangalore-560090, India.

 

Dr. H. B. Niranjan
Department of Mechanical Engineering, Sambhram Institute of Technology, Lakshmipura Cross, MS Palya, Jalahalli East, Bangalore-560097, India.

 

Dr. S. Raghavendra
Department of Mechanical Engineering, Sai Vidya Institute of Technology, Bangalore-560 064, India.

Please see the link here: https://stm.bookpi.org/CICMS-V9/article/view/14333