The present study assesses the biocompatibility of pure
zirconia discs ZrO2 compared to yttria–zirconia discs (Y-TZP) as
well as the influence of the surface topography through the combination of a
conventional toxicological assay, morphological observations, and a
transcriptomic analysis on an in vitro model of human Saos-2 bone cells. The
direct anatomical and functional bond between the surface of an implant and
living neoformed bone is known as the osseointegration of implants. Implants'
biological compatibility is contingent upon a number of factors, including
surface topography, chemical composition, material type, and mechanobiological
characteristics. Similar cell proliferation rates were observed between ZrO2
and Y-TZP discs and control cells, independent of surface topography, for up to
96 hours of exposure. High cell density was similarly observed on the surfaces
of both materials. It could be interesting to perform a comparative
transcriptomic study between rough and mirror-polished Y-TZP samples to observe
a potential influence of the surface topography on the gene expression and to
better understand the underlying mechanisms. Relevantly, only 110 transcripts
were differentially expressed across the human transcriptome, consistent with
the excellent biocompatibility of Y-TZP reported in the literature. These
deregulated transcripts are mainly involved in two known metabolic pathways,
the first being linked to 'mineral absorption' and the second to 'immune
response'. These observations suggest that Y-TZP is an interesting candidate
for application in implantology. Y-TZP is a serious candidate for implantology
in general. However, further biocompatibility and biomechanical studies are
needed to position Y-TZP as a reference material in oral implantology and to
find the best roughness level for this material.
Author(s)details:-
Alex Tchinda
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy,
France.
Laëtitia Chézeau
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy,
France.
Gaël Pierson
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy,
France.
Richard Kouitat-Njiwa
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy,
France.
B. H. Rihn
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy,
France.
Pierre Bravetti
Jean Lamour Institute, University of Lorraine, UMR 7198, 54011 Nancy,
France.
Please See the book
here :- https://doi.org/10.9734/bpi/cmsdi/v2/12008F
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