Back Ground: Diabetes is a metabolic disease most often
associated with complications when the biological parameters are uncontrolled,
so management of diabetes remains a challenge in Africa. The increasement of
this disease is associated with the ageing population, economic development,
increasing urbanization, a less healthy diet and decreased physical activity.
Objective: The aim of this study was to find a relationship
between the polymorphism of the gene encoding for angiotensin converting enzyme
(ACE) and type 2 diabetes (T2D) in Gabonese subjects.
Method and Materials: This study was carried out in the
laboratory of the Research Unit of the University of Health Sciences. The study
population consisted of 225 subjects. This panel was composed of 88 controls
(normoglycemic and non-hypertensive and not having a family history of
diabetes) and 137 type 2 diabetic individuals. The genotypic analysis of the
ACE gene of the different subjects was carried out by the technique of
Polymerase Chain Reaction (PCR). Categorical and continuous variables were
compared between diabetic patients and controls using the Chi-square test (X2)
for categorical and the ANOVA test for continuous.
Results: The distribution of DD, ID, and II genotypes in
controls and diabetics was 63.6%, 33%; 3.4% respectively and 65.7%; 31.4%;
2.9%. In addition, the allelic distribution showed that the alleles I and D in
the controls and the diabetic subjects had proportions of 19.9%; 80.1% vs.
18.6%; 81.4% respectively. The genotypic and allelic differences between the
two groups were not significant (p = 0.78).
Discussion and Conclusion: Therefore the allele D would not
be the factor involving the I/D polymorphism in the occurrence of type 2
diabetes (T2D) in the Gabonese population. Plasma ACE activity in diabetic
patients, as well as analysis of other genes may be related to the onset of the
disease in order to highlight a genetic relationship linked to the occurrence
of the pathology which can lead to better management of the patients and especially
a new clinical approach for an effective diagnosis of diabetics.
Ndong Atome Guy Roger,
Laboratory of Research in Biochemistry (LAREBIO), University of Sciences and Technology of Masuku, Franceville, Gabon.
Ovono Abessolo Felix,
Department of Chemistry and Biochemistry, University of Health Sciences (USS) Libreville, Gabon.
Mbang Bengone Aude Synthia,
Laboratory of Research in Biochemistry (LAREBIO), University of Sciences and Technology of Masuku, Franceville, Gabon and Department of Chemistry and Biochemistry, University of Health Sciences (USS) Libreville, Gabon.
Ollomo Benjamin,
Department of Chemistry and Biochemistry, University of Health Sciences (USS) Libreville, Gabon.
Yacka Laurianne,
Department of Chemistry and Biochemistry, University of Health Sciences (USS) Libreville, Gabon.
Lebibi Jacques,
Laboratory of Research in Biochemistry (LAREBIO), University of Sciences and Technology of Masuku, Franceville, Gabon and Chemistry Unit, Faculty of Science and Technology, University of Sciences and Technology of Masuku, Franceville, Gabon.
Ngou-Milama Edouard,
Department of Chemistry and Biochemistry, University of Health Sciences (USS) Libreville, Gabon.
Please see the link here: https://stm.bookpi.org/ANUMS-V2/article/view/13093
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