Aims: Many plans can improve the cytotoxic action of a plant extract. A previous study stated that a plant extract having uncontaminated activity and loaded into jam nanoparticles (GNPs) was able expected improved the uncontaminated activity. The purpose concerning this study was to judge whether Cantigi (Vaccinium varingiaefolium Blume Miq.) leaf extract tricky into GNPs was able to specify cytotoxic activity (CA) bettering on T47D cells compared to the raw extract.Methodology: The extraction of Cantigi leaf powder secondhand hexane (HX) and then ethyl acetate (EA). The EA extract was therefore prepared into GNPs utilizing the desolvation method and reformed at two process parameters (joining speed and temperature) and three material concentrations (poloxamer 188, jam, and glutaraldehyde). The EA extract-loaded GNPs formed were typified for particle capacity (PS), polydispersity index (PI), zeta potential (ZP), entrapment adeptness (EE), CA (IC50, using the MTT arrangement on T47D cells), FTIR sketch, and morphology.Results: Compared to the EA extract (IC50 = 75.16 μg/mL), the EA extract-tricky GNPs manufactured utilizing the formulation treated at 500 rpm and 40oC provided the highest cytotoxic endeavor (IC50 = 16.88 μg/mL).Conclusion: The results showed that EA extract-intoxicated GNPs improved the CA of the EA extract on T47D containers significantly.
Author(s) Details:
Kosasih Kosasih,
Doctoral Program of Pharmaceutical Sciences, Faculty of Pharmacy,
Universitas Pancasila, Jakarta, Indonesia.
Effionora Anwar,
Doctoral
Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Pancasila,
Jakarta, Indonesia.
Diky Mudhakir,
School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia.
Agus Supriyono,
Badan Pengkajian dan Penerapan Teknologi, Puspiptek Serpong,Kota
Tangerang Selatan, Indonesia.
Please see the link here: https://stm.bookpi.org/NRAMMS-V1/article/view/11792
No comments:
Post a Comment