Effect of Mitochondrial Dysfunction for Atrial Fibrillation Associated with Aging | Chapter 9 | Current Progress in Medicine and Medical Research Vol. 8

The occurrence of atrial fibrillation (AF) increases with age, and telomere distance (TL) gradually diminishes with age. However, whether TL is had connection with AF is still inconclusive, and the exact means by which slumping causes the increased occurrence of AF is still unclear. We hypothesize that TL is compared with crumbling-related AF what mitochondrial dysfunction plays a role in this place. This research recruited 96 elderly male victims with AF the one were admitted to the Second Medical Center of Chinese PLA General Hospital from April to October 2018. After corresponding by age and gender, 96 non-AF aged male patients the one were admitted to the hospital for medical examination during the unchanging period were picked as the control group. Anthropometric, clinical, and lab analyses were performed on all cases. The mitochondrial membrane potential (MMP) of minor blood leukocytes was discovered as the indicator of mitochondrial function. Compared accompanying the control group, the leukocyte telomere time (LTL) was significantly shorter (P < 0.001), and the level of PGC-1α in antitoxin was significantly lower in AF victims. Additionally, in subjects outside any added diseases, the AF patients had lower MMP when distinguished with the control group. Multivariate logistic reversion confirmed that LTL (OR 0.365; 95% CI 0.235-0.568; P < 0.001) and antitoxin PGC-1α (OR 0.993; 95% CI 0.988-0.997; P = 0.002) were inversely guide the presence of AF. In addition, ROC analysis designated the potential diagnostic profit of LTL and serum PGC-1α accompanying AUC values of 0.734 and 0.633, individually. This research concludes that LTL and antitoxin PGC-1α are inversely correlated accompanying the occurrence of becoming older-related AF, at which point and that mitochondrial dysfunction plays a meaningful role in this.

Author(s) Details:

Chuanbin Liu,
Western Medical Branch of the Chinese PLA General Hospital, Beijing 100853, China.

Yating Chen,
Department of Cardiology, the Sixth Medical Centre of Chinese PLA General Hospital, Beijing 100048, China and Medical School of Chinese PLA, Beijing 100853, China.

Yang Li,
Department of Cardiology, the Sixth Medical Centre of Chinese PLA General Hospital, Beijing 100048, China.

Please see the link here: https://stm.bookpi.org/CPMMR-V8/article/view/11740