The measurement of paracetamol and nimesulide in combination tablet dose forms was explored using new, quick, inexpensive, and straightforward spectrophotometric approaches. Paracetamol is an analgesic and an antipyretic, and nemesulide is a nonsteroidal anti-inflammatory medication. There have been devised easy, accurate, exact, repeatable, no-preparation, cost-effective methods for estimating both paracetamol and nimesulide simultaneously in tablet dosage form. The procedure uses two analytical wavelengths for both medicines, 245.5 nm and 299.5 nm, in methanol-distilled water to generate and solve a simultaneous equation (50:50). Nimesulide and paracetamol both exhibit linearity in the concentration ranges of 1–11 and 5–30 g/mL and 245.5–299.5 nm, respectively. Recovery studies for Paracetamol and Nimesulide showed accuracy of the suggested approach to be 99.56% and 100.14%, respectively. The proposed approach is suitable for routine analysis because to its efficiency, simplicity, accuracy, sensitivity, and specificity.
Author(s) Details:
Rupali Kirtawade,
Govt. College of Pharmacy, Karad-415 124, (Satara), Maharashtra, India.
Pallavi Salve,
Govt. College of Pharmacy, Karad-415 124, (Satara), Maharashtra, India.
Chhotaram Seervi,
Govt. College of Pharmacy, Karad-415 124, (Satara), Maharashtra, India.
Anita Kulkarni,
Govt. College of Pharmacy, Karad-415 124, (Satara), Maharashtra, India.
Pandurang Dhabale
Govt. College of Pharmacy, Karad-415 124, (Satara), Maharashtra, India.
Please see the link here: https://stm.bookpi.org/CAPR-V7/article/view/8371
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