The goal of this research is to see if females with balanced translocation (BT) have a normal ovarian response when compared to women with normal karyotype XX. And, in males with BT, to see if their spermiogram is impaired in comparison to guys with a normal XY karyotype.
Methods: Between 2008 and 2016, 3249 karyotyped individuals were analysed in a public IVF centre, 2276 women and 973 men. The results of the cycle, the oocytes, and the embryos were studied. A spermiogram of 19 males with BT was compared to a spermiogram of 93 healthy XY patients. In addition, 12 women with BT were compared to 93 women with normal karyotype XX (CN). A 12-patient equivalent control group (EQc) was also chosen to ensure that the BT statistical contrast with normal karyotype in both members of the marriage was accurate. All of the cycles' results were compared.
The results showed that 19 men (1.9%) and 12 women (0.5%) had BT. Men in the BT group were older than those in the CN group (37.865.62 vs. 40.26.18; t57,590 = -3,169, p = 0.02). Fresh spermatozoa concentration was significantly lower (37.69 37.36 vs. 23.49 22.75 mill/ml; t65,04 = 3,191, p = 0.002), while motility (A+B) was not different (44.8 17.96 vs. 42,28 16.60 in control vs. pathologic; p=0.423). Progressive motility (A + B) MSR (motile spermatozoa recovery) (70.86 20.57 vs. 80.25 18.94 control vs. pathologic; t292 = -2,589, p = 0.010) was observed after capacitation. BT women were older than CN women (36.554.06 vs. 33.963.70; p0.001), although FSH levels were similar (6.541.30 vs. 6.391.72; p=0.618). BT had a higher BMI (26.73+5.36 vs. 24.32+3.98; p=0.011) than the other groups. There was no statistical difference in the number of mature MII oocytes recovered in BT (11.284.51 vs. 9.686.13; p=0.135), similar maturation rate (90.38 percent vs. 89.20 percent; p=0.602), and larger number of divided embryos (9.033.53 vs. 7.285.25; p=0.09). There were no substantial differences in any of the examined characteristics when compared to EQc to account for differences in age, BMI, and FSH values.
Conclusions: Men with a BT have sperm quality characteristics that are worse than typical XY males. In males with abnormal spermiograms, a karyotype should be obtained prior to reproductive treatment. Infertile women with normal karyotype XX do not have a different response pattern to COS (controlled ovarian stimulation) than BT carriers. An ICSI cycle with PGT and thorough genetic counselling are strongly recommended in both circumstances.Author(S) Details
Salma Kaddouri-Kaddouri
Universidad de La Laguna (ULL), Santa Cruz de Tenerife, Canary Islands, Spain.
Cintia Concepcion-Lorenzo
Unidad de Reproducción Humana (URH). Complejo Hospital Universitario de Canarias (CHUC), La Laguna, Santa, Cruz de Tenerife, Canary Islands, Spain.
Rubí Rodríguez-Díaz
Universidad de La Laguna (ULL), Santa Cruz de Tenerife, Canary Islands, Spain and Unidad de Reproducción Humana (URH). Complejo Hospital Universitario de Canarias (CHUC), La Laguna, Santa, Cruz de Tenerife, Canary Islands, Spain.
Stephany Hess-Medler
Universidad de La Laguna (ULL), Santa Cruz de Tenerife, Canary Islands, Spain.
Jonay González-Pérez
Unidad de Reproducción Humana (URH). Complejo Hospital Universitario de Canarias (CHUC), La Laguna, Santa, Cruz de Tenerife, Canary Islands, Spain.
Rebeca Vaca-Sánchez
Unidad de Reproducción Humana (URH). Complejo Hospital Universitario de Canarias (CHUC), La Laguna, Santa, Cruz de Tenerife, Canary Islands, Spain.
Delia R. Báez-Quintana
Universidad de La Laguna (ULL), Santa Cruz de Tenerife, Canary Islands, Spain and Unidad de Reproducción Humana (URH). Complejo Hospital Universitario de Canarias (CHUC), La Laguna, Santa, Cruz de Tenerife, Canary Islands, Spain.
Raquel Blanes-Zamora
Universidad de La Laguna (ULL), Santa Cruz de Tenerife, Canary Islands, Spain and Unidad de Reproducción Humana (URH). Complejo Hospital Universitario de Canarias (CHUC), La Laguna, Santa, Cruz de Tenerife, Canary Islands, Spain.
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