Effectiveness of Trimetazidine, a Cytoprotective Agent in Ischemic Heart Disease | Chapter 7 | Technological Innovation in Pharmaceutical Research Vol. 6

 The goal of metabolic medicines like trimetazidine is to provide cytoprotection in patients with ischemic heart disease (IHD) by inhibiting cardiac fatty acid oxidation and enhancing myocardial glucose utilisation. Trimetazidine is a potentially life-saving medicine that works by changing the metabolism of cardiac cells so that glucose instead of fat is used. To demonstrate the effectiveness of trimetazidine in decreasing angina and enhancing exercise tolerance.

Methods: On day 0 of the study, 50 patients with chronic stable angina who were receiving conventional treatment had a stress test (treadmill) to assess parameters such as effort duration and ST-segment alterations at the end of the exercise. Following the evaluation, the patients will be administered trimetazidine at a daily dose of 60 mg (in three divided doses) for six weeks. A second stress test evaluation was performed after the time limit had expired.

The participants in this study were 50 patients with chronic stable angina, 35 of whom were men and 15 of whom were women. Trimetazidine consumption resulted in an increase in mean exercise time from 7.086.96 to 8.30.75, as well as good symptomatic improvement (in 31 patients). In 15 patients, there was no discernible increase in effort duration (>1 minute). There were no serious side effects noted, thus the medicine was not stopped.

Conclusion: Trimetazidine is an effective anti-anginal as monotherapy and as a cytoprotective adjuvant to conventional anti-anginals.

Author (s) Details

Sharanjit Kaur
Department of Pharmacology, Maharishi Markandeshwar Medical College and Hospital, Kumarhatti, Solan, Himachal Pradesh, India.

Harinder Jot Singh
Department of Physiology, Maharishi Markandeshwar Medical College and Hospital, Kumarhatti, Solan, Himachal Pradesh, India.

Sanjay Nayyar
Department of Medicine Gian Sagar Medical College, Rajpura, Punjab, India.

Navpreet Kaur
Department of Pharmacology, Maharishi Markandeshwar Medical College and Hospital, Kumarhatti, Solan, Himachal Pradesh, India.

Sami Manzoor
Department of Pharmacology, Maharishi Markandeshwar Medical College and Hospital, Kumarhatti, Solan, Himachal Pradesh, India.

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