Experimental and Theoretical Study on Lipophilicity of Synthetic 1,2-dithiole Derivatives | Chapter 8 | Current Perspectives on Chemical Sciences Vol. 10

 The goal of this research is to establish the log Pwo partition coefficients of eleven compounds, including dithiolethiones, dithiolone, nitrone, 1,2-dithiole-3-imine, and other compounds, using two experimental methods: UV-visible and HPLC. We confirm the results using a theoretical technique for estimating log Pwo values, following the approach of the standard shake-flask approach. The value of the unknown fragmental constant of imine(C=N) and the value found of imine fC=N underlined in the calculatation of log Pwo (N-p-nitrophenyl 5-phenyl-1,2-dithiole-3-imine) are the other parts of this work. The computed log Pwo value was then compared to the experimental research. The results reveal that: I dithiolones are more hydrophilic than dithiolethiones; and (ii) log Pwo values of bromine, imine, and nitrone derivatives have recently been reported in tests. The experimentally observed and computed log Pwo values are in good agreement, according to our research.

Author (s) Details

Z. Rahmani
Laboratoire de Valorisation et Promotion des Ressources Sahariennes, Université Kasdi Merbah de Ouargla, 30000 Ouargla, Algeria.

M. Saidi
Laboratoire de Valorisation et Promotion des Ressources Sahariennes, Université Kasdi Merbah de Ouargla, 30000 Ouargla, Algeria.

M. Yousfi
Laboratoire des Sciences Fondamentales, Université Amar Telidji, (16000) Laghouat, Algeria.

M. Dakmouche
Laboratoire de Valorisation et Promotion des Ressources Sahariennes, Université Kasdi Merbah de Ouargla, 30000 Ouargla, Algeria.

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