Bucillamine as An Efficient H Atom Donor Protects High-Molar-Mass Hyaluronan from Oxidative Degradation by Effective Scavenging of Free Radicals

 Bucillamine has been shown to preserve high-molecular-mass hyaluronan from degradation caused by a free-radical-generating system containing cupric ions and ascorbate. We adopted a multimodal strategy in this investigation, employing a range of methodologies such as non-isothermal chemiluminometry, thermogravimetry, and differential scanning calorimetry to characterise the hyaluronan fragments produced.

Bucillamine was found to significantly slow the oxidative degradation of high-molar-mass hyaluronan in our tests. The results, particularly the decrease in chemiluminescence intensity and removal of the differential scanning calorimetry exotherm (at 270oC) for hyaluronan fragments, may indicate the need for more research into the mechanism(s) of action of bucillamine in this process.

Author (s) Details

Katarína Valachová
Centre of Experimental Medicine, Slovak Academy of Sciences, SK-84104 Bratislava, Slovakia.

Jozef Rychlý
Polymer Institute, Slovak Academy of Sciences, SK-84541 Bratislava, Slovakia.

Ivica Janigová
Polymer Institute, Slovak Academy of Sciences, SK-84541 Bratislava, Slovakia.

Katarína Csomorová
Polymer Institute, Slovak Academy of Sciences, SK-84541 Bratislava, Slovakia.

Ivo Juránek
Centre of Experimental Medicine, Slovak Academy of Sciences, SK-84104 Bratislava, Slovakia.

Ladislav Šoltés
Centre of Experimental Medicine, Slovak Academy of Sciences, SK-84104 Bratislava, Slovakia.

View Book :- https://stm.bookpi.org/CACB-V7/article/view/1193