Tuesday, 11 October 2022

Determining the Effect of Aqueous Extract of Truffle on Some Antioxidants in Rats Exposed to Oxidative Stress Induced by Hydrogen Peroxide | Chapter 3 | Challenges and Advances in Pharmaceutical Research Vol. 7

 The goal of the current study was to determine the ability of different concentrations of the aqueous extract of truffle water extract to mitigate the effects of oxidative stress during periods of 0, 15, and 30 days by measuring the following parameters in serum: glutathione (GSH), malondialdehyde (MDA), the activity of super oxide dismutase enzyme (SOD), and the peroxynitrate radial concentration (ONOO). Five groups of 50 male rats, each weighing 300–400 g and being 3–4 months old, were created. group (2) had 0.5% H2O2 added to the water, group (3) got H2O2 and 20% truffle water extract, group (4) had tap water as the control group, H2O2 and 40% truffle water extract were given to group , whereas 60% truffle water extract was given to group (5). Hydrogen peroxide treatment significantly decreased (P 0.05) the GSH and SOD activities while raising the serum levels of MDA and ONOO when compared to the control group. Because of its impact on the levels of GSH, SOD, MDA, and ONOO in the blood serum at various trial times, the findings of administering various concentrations of Truffle Water Extract on rats showed a small protection against oxidative stress generated by Hydrogen Peroxide.


Author(s) Details:

Hani Sabbar Ayed,
Department Food of Science, College of Agriculture, Tikrit University, Iraq.

Abdulkhaleq Sulaimain Khalaf,
Department Food of Science, College of Agriculture, Tikrit University, Iraq.

Taha Mohammed Taki Mohammed,
Department of Science, College of Basic Education, Mosul University, Iraq.

Please see the link here: https://stm.bookpi.org/CAPR-V7/article/view/8366

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