The bacteria that causes tuberculosis, Mycobacterium tuberculosis, is notorious for acquiring resistance to monotherapy. Patients are given a combination of antitubercular drugs for months to years to prevent the emergence of resistance, which can cause negative effects. Hepatotoxicity is one of the most common side effects of antitubercular drugs.
The goal of this investigation was to see if -tocopherol could protect albino rabbits' livers from experimentally induced hepatotoxicity.
Methods: Thirty rabbits of either sexe were used in this experiment. They were split into three groups, each with ten animals. Hepatotoxicity is generated in rabbits in an experimental setting using a conventional technique. Normal saline (10 ml/kg bw) was given to Group I. The first-line antitubercular medicines isoniazid (5 mg/kg bw), rifampicin (20 mg/kg bw), and pyrazinamide (25 mg/kg bw) were given to rabbits in group II at the same time. Along with group II medicines, group III received - tocopherol 200 mg/kg bw. For 90 days, all of the medications were taken orally. Blood samples were taken on the last day of the experiment to look into the plasma levels of alanine aminotransferase (ALT), alkaline phosphatase (ALP), and serum total bilirubin.
After 90 days of oral antitubercular treatment, serum levels of ALT were found to be significantly raised. When -Tocopherol was given in doses of 200mg/kg bw for the same duration as antitubercular medicines, there was a statistically significant drop in ALT levels. Serum ALP and serum total bilirubin yielded similar results.
Conclusions: In albino rabbits, -tocopherol (200 mg/kg bw, oral) had a hepatoprotective effect against antitubercular drug-induced hepatotoxicity.Author(S) Details
Rajiv Nehra
Department of Biochemistry, LLRM Medical College, Meerut (U.P.), India.
Pinki Vishwakarma
Department of Pharmacology, LLRM Medical College, Meerut (U.P.), India.
Manju Nehra
Dental Surgeon, C.H.C. Siyana, Bulandshahr, (U.P.), India.
Shashank Tyagi
Department of Biochemistry, LLRM Medical College, Meerut (U.P.), India.
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