Coronavirus infection in 2019 (COVID-19) A pandemic has spread to practically every country on the planet, and the crisis is still having a huge influence on the number of people who have died and worldwide economic growth. The current state of knowledge about its pathophysiology is important for dealing with the current public health crisis. This review will look at published studies about COVID-19 to see what information there is on the molecular pathways that underlie the changes caused by SARS-CoV-2. When the SARS-CoV-2 S protein reaches cells with ACE2 receptors, which are primarily found in the upper respiratory tract, followed by the oral cavity, and, in a lesser degree, the conjunctiva, the COVID-19 virus infects people. SARS-CoV-2 aggravation is primarily caused by inflammation and thrombus development in symptomatic patients. This is due to a regulatory imbalance created by the loss of ACE2 receptors, which serves to activate the regulatory axis Ang-II ACE2 Ang-(1-7) MAS receptor, which counteracts the deleterious effects of Ang-II. SARS-CoV-2 uses the ACE2 as a primary receiver, allowing it to activate virulence mechanisms in the host.
Author(S) Details
Nestor Cahui Galarza
Biomedical Sciences, National University of the Altiplano - Puno, Puno, Perú. and SAMYECO S.R.L. - Juliaca, Puno, Perú.
María de los Ángeles Monge Condori
National University of Moquegua, Mcal Nieto, Moquegua, Perú.
View Book:- https://stm.bookpi.org/RDMMR-V6/article/view/4516
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