Background: The Indian scenario is unique in that it has a high prevalence of Candida glabrata or Candida parapsilosis isolation in all age groups. As a result, a reliable susceptibility testing approach as a guide to selecting and monitoring antifungal therapy is more important than ever.
The goal of this study was to identify and isolate Candida species from patients admitted to our hospital's ICUs, as well as to test their susceptibilities to various antifungal drugs, in order to determine the local resistance pattern and provide guidance for empirical treatment.
Methods: In this investigation, 37 candida strains were identified (4 Candida albicans, 33 Non-albicans Candida strains). Conventional, biochemical, and molecular approaches were used to identify Candida species. Antifungal susceptibility tests were performed using the broth microdilution method and E- tests as recommended by the National Committee for Clinical Laboratory Standards for amphotericin B, fluconazole, itraconazole, ketoconazole, and voriconazole (NCCLS).
The most common Candida species were C. tropicalis (43.2 percent), C. parapsilosis (24.3 percent), C. krusei (16.2 percent), C. albicans (10.8 percent), and C. glabrata (10.8 percent) among 37 Candida strains (2.7 percent ). Four strains (10.8 percent) were resistant to all azoles, including two Candida albicans resistant to fluconazole, one Candida krusei, and one Candida parapsilosis resistant to all azoles.
Conclusions: Non-Albicans Candidaemia continues to be associated with significant morbidity and mortality. In India, Candida species are the most commonly isolated pathogen from patients admitted to tertiary care facilities. As a result, antifungal susceptibility testing is essential for selecting appropriate and effective antifungal therapy.Author(S) Details
Bilal Ahmad Wani
Department of Microbial Biotechnology, Amity Institute, Noida, Delhi, India.
Mohd Rafiq Lone
Department of Pediatrics, SKIMS Medical College, Bemina Srinagar, Jammu and Kashmir, India.
Najmus Saqib
Department of Pediatrics, GMC Doda, Jammu and Kashmir, India.
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