Primary adrenal insufficiency (PAI) in children is a rare but potentially fatal condition. Weakness, weariness, anorexia, abdominal pain, weight loss, orthostatic hypotension, salt desire, and hyperpigmentation are some of the current symptoms.
The goal of this research was to determine the cause of PAI in a big referral, teaching hospital in Riyadh, Saudi Arabia.
Materials and Procedures: This is a retrospective hospital-based study that took place between January 1989 and December 2014 at King Khalid University Hospital (KKUH). Medical records of a patient diagnosed with primary adrenal insufficiency were reviewed. The diagnosis was made based on the patient's medical history, physical examination, and low glucocorticoid levels and elevated adrenocorticotropic hormone levels (ACTH). The results of appropriate laboratory and radiographic tests were also examined.
Results: A total of 125 individuals with primary adrenal insufficiency were seen between January 1989 and December 2014. 85.5 percent of the participants had inherited diseases such as congenital adrenal hyperplasia and hypoplasia. Variable autoimmune-mediated etiologic diagnosis, which accounted for 13% of the cases, was also seen. Various laboratory and radiological investigations should be planned as needed.
Conclusion: Although congenital adrenal
hyperplasia was the most common cause, congenital adrenal hypoplasia should
also be considered. In some cases, determining the presence of PAI can be
difficult, hence suitable serological testing is recommended.
Author (S) Details
N. A. Al-Jurayyan
Department
of Pediatrics, College of Medicine and King Khalid University Hospital (KKUH),
King Saud University Medical City, Riyadh, Saudi Arabia.
View Book :- https://stm.bookpi.org/NFMMR-V10/article/view/3506
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