Mechanical investigations are used to develop novel products for the prevention of traumatic brain injuries. To improve protective equipment, however, there is a necessity for new and more advanced analyses focusing on molecular levels. We recently looked at the mature protein laminin LN521 to see how it reacted to dynamic and semi-static forces, and discovered that the laminin structures were significantly fragmented and aggregated. The goal of this study was to examine the influence of polymer materials on preventing the denaturement of the cell membrane protein Laminin, and thereby minimising head impacts, utilising two separate mechanical methods: denatured electrophoresis and electron microscopy. As a result of dynamic impacts without and with polymer materials, the force as well as the translational acceleration were significantly reduced, with up to a 50% reduction. In addition, after a dynamic impact, mature laminin was employed in the lab to see if this molecule might be used as a complimentary analyzer to mechanical methods while looking for the best protective materials. As determined by denatured electrophoresis and electron microscopy, the polymer materials have the ability to protect the laminin structures against fragmentation and aggregation. As a result, proteins may be used to supplement today's computer simulations and mechanical investigations in the search for better protection systems for the skull bone and brain tissue. The current finding suggests that laminin structures could be a useful tool for identifying new structures at the molecular level in the hunt for better protective materials for brain tissue during physical activity and accidents.
Author (S) Details
Hans von Holst
Section of Neurosurgery, Karolinska University Hospital, Sweden and Section of Research, MIPS Company, Sweden.
Pasi Purhonen
Department of Biosciences and Nutrition, Karolinska Institute and School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Huddinge, Sweden.
Daniel Lanner
Section of Research, MIPS Company, Sweden.
Ramakrishnan Balakrishnan Kumar
Department of Biosciences and Nutrition, Karolinska Institute and School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Huddinge, Sweden.
Hans Hebert
Department of Biosciences and Nutrition, Karolinska Institute and School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Huddinge, Sweden.
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