Insulin-like growth factors (IGFs) are important for neuronal development, differentiation, survival, and synapse formation. IGF-1 has the greatest impact on the developing brain. We shall attempt to answer the following questions in this paper: Why is it vital to conduct research on children? What clinical research have been conducted in the areas of neonatal asphyxia, infantile spasms, progressive encephalopathy–hypsarrhythmia–optical atrophy (PEHO) syndrome, infantile ceroid lipofuscinosis (INCL), autism spectrum disorders (ASD), and subacute sclerosing panencephalitis (SSPE)? Is there a therapeutic potential for IGF? Are there any therapeutic options?
The pathophysiology of several neurological problems in children that lead to intellectual disability, both acute and chronic, was investigated using IGFs in serum and CSF, as well as clinical data from the Finnish study and the literature.
Finally, there are high prospects for the therapeutic use of IGF-1 in the treatment of several neurological illnesses, including ASD.
Author (S) Details
Raili Riikonen
Children’s Hospital, University of Eastern Finland and Kuopio University Hospital,P.O. Box 1627, FI-70211 Kuopio, Finland.
View Book :- https://stm.bookpi.org/NVST-V3/article/view/3724
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