Diabetes is a chronic group of metabolic diseases
characterised by the constantly elevated blood glucose levels, which leads to
the glycation of body proteins, which may further cause serious complications.
In recent years, the use of complementary medicine has seen significant growth,
particularly in dietary interventions and traditional plant-based therapies
derived from systems such as Ayurveda. No systematic studies have been reported
for its wound healing and anti-diabetic properties of Sarkaraikolli. An effort
has been made to establish the wound healing and anti-diabetic properties of
the polyherbal formulation Sarkaraikolli. In this model, animals were
administered with test and standard samples by the oral route. Frequently blood
samples were taken and examined for blood glucose levels, which were assessed
using a glucometer. The animals were sacrificed 2 hours on the 21st day after
the treatment by cervical dislocation, and biochemical studies were performed.
The blood samples were collected, and serum was separated by centrifugation at
3000 rpm for 15 minutes after a retro-orbital puncture. Different procedures
were performed for the determination of liver enzyme tests. In the model of
anti-diabetic animals were evenly divided into 5 groups. Group-1 and Group-2
served as untreated and model controls respectively, while Group-3, 4, and 5
were the treatment groups which were simultaneously treated with standard, 250
and 500 mg/kg extract respectively after glucose loading. Sarkaraikolli
possesses significant anti-diabetic and wound healing activity when compared to
the conventional medicine like Glibenclamide. Significant anti-diabetic action
is visible due to lower blood glucose levels and maintenance of steady body
weights. Sarkaraikolli wound healing activity is demonstrated by higher wound
healing activity as compared to the standard medication. The biochemical
parameters like SGOT, SGPT and ALP were determined by using the analytical
kits. The results shown by the treatment of Sarkaraikolli were significant and
are closer to the control group. This research work proved that Sarkaraikolli
possesses significant anti-diabetic and wound-healing activity. When compared
to conventional medicine, Glibenclamide, a significant anti-diabetic action is
visible due to lower blood glucose levels and maintenance of steady body
weights. Sarkaraikolli's wound healing activity is demonstrated by higher wound
healing activity when compared to the standard drug (Nitrofurazone).
Author(s) Details
S. Sundar
Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for
Women, Enikepadu, Vijayawada, Andhra
Pradesh, India.
A. Bhavana
Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for
Women, Enikepadu, Vijayawada, Andhra Pradesh, India.
N. K. S. Neeraja
Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for
Women, Enikepadu, Vijayawada, Andhra Pradesh, India.
D. Prasanna
Department of Pharmaceutical Chemistry, Vijaya Institute of Pharmaceutical
Sciences for Women, Enikepadu, Vijayawada, Andhra Pradesh, India.
R. Sunitha
Department of Pharmacognosy, Vijaya Institute of Pharmaceutical Sciences
for Women, Enikepadu, Vijayawada, Andhra Pradesh, India.
Please see the book here:- https://doi.org/10.9734/bpi/psnid/v8/6122
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