A serious demographic and public health concern, age-related
macular degeneration (ARMD) continues to be the leading cause of permanent loss
of vision in the elderly globally. Conventional therapeutic approaches,
including anti-VEGF injections and laser-based strategies, offer only temporary
disease control and are limited in their ability to modify the underlying
pathophysiology. It involves creating techniques to ensure sustained delivery
of a range of antiangiogenic proteins. These are repetitive intravitreal
injections, which put the patient at high risk of infection, costly drugs, low
compliance, disparities in access, healthcare burden, increase the
doctor-patient conflict, and are hectic for the elderly population. It is a
degenerative disease that results in central vision loss by affecting the
choriocapillaris, photoreceptors, retinal pigment epithelium, and macula. In
recent years, gene therapy has developed as a transformational approach,
integrating molecular genetics, vector engineering, and precision medicine
principles to target the fundamental causes of ARMD. Gene therapy has emerged
as a promising substitute, an innovative approach to treating ARMD by replacing
faulty genes with healthy ones. Viral non-integrating vectors, such as
Adeno-Associated Viral (AAV), act as envelopes that carry encoded genetic
messages without impacting native cellular DNA. This chapter addresses the
evolving importance of precision gene therapy in ARMD management, emphasising
developments in gene replacement techniques. The high potential and efficiency
of this therapy could make it an effective method, providing hope for patients
and future healthcare.
Author(s) Details
Asra Warees
Optometry Section, Paramedical College, Faculty of Medicine, Aligarh Muslim
University, Aligarh, Uttar Pradesh, India.
Aleena Saeed
Optometry Section, Paramedical College, Faculty of Medicine, Aligarh Muslim
University, Aligarh, Uttar Pradesh, India.
Wasil Hasan
Biochemistry Section, Paramedical College, Faculty of Medicine, Aligarh Muslim
University, Aligarh, Uttar Pradesh, India.
Saima Ahsan
Optometry Section, Paramedical College, Faculty of Medicine, Aligarh Muslim
University, Aligarh, Uttar Pradesh, India.
Mohd Faraz
Department of Radiodiagnosis, J.N. Medical College, Paramedical College,
Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Please see the book here :- https://doi.org/10.9734/bpi/msraa/v11/6257
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