An Update on Clonal Hematopoiesis: Insights from Genetic and Genomic Perspectives | Chapter 11 | An Overview of Disease and Health Research Vol. 5

 

A prevalent biological condition in middle-aged and older people is clonal hematopoiesis (CH), which is defined as an excessive contribution to the formation of circulating blood cells by a single genetically modified hematopoietic clone in the absence of diagnostic evidence of a hematologic malignancy. Clonal haematopoesis is often caused by a hematopoietic stem or progenitor cell acquiring one or more somatic mutation repertoires. CH is quite frequent as people age, and it raises the chance of developing overt hematologic cancer as well as all-cause mortality and concomitant conditions, including diabetes and cardiovascular disease. Genetic and concurrent non-genetic risk factors (such as high blood pressure or smoking cigarettes) determine the level of risk. Since it is currently unknown how to reduce these risks, the prospect of future clinical repercussions may add to anxiety and uncertainty, even though the chance of clonal advancement or concomitant events in a single patient with clonal hematopoiesis may be minimal. Given this context, the goal of the current review is to examine the body of recent research in the field. Background information on somatic mosaicism, haematological disorders, and CH is included in the review to provide background literature. In-depth discussions of CH nosology, detection, and CH involvement in haematological and lymphoid disorders are described, emphasising novel findings with research and clinical medicine implications. The role of driver genes and non-involvement in somatic events raises a few questions. Using the lens of genetics and genomics, the fitness, selection and multiplication of clones are discussed. Finally, prevalent methods for intervention and knowledge gaps are discussed, thus covering a spectrum of topics.

 

 

Author(s) Details

Mahalakshmi B.R
Department of Zoology, Government Science College, Nrupathunga University, Nrupathunga Road, Bangalore, 560001, India.

 

Priya M.D
Department of Zoology, Government Science College, Nrupathunga University, Nrupathunga Road, Bangalore, 560001, India.

 

Rajesha S
Department of Genetics and Zoology, Government Science College, Nrupathunga University, Nrupathunga Road, Bangalore, 560001, India.

 

Latha K
Maharanis Science College for Women, Autonomous JLB Road, Mysore, Affiliated to University of Mysore, Karnataka, India.

 

Ranjini
Department of Biotechnology, Sir MV Government Science College Bhadravathi, Karnataka, India.

 

Shailasree Sekhar
Department of Biochemistry, School of Life Sciences, JSS Academy of Higher Education and Research, Mysore, India.

 

Shreya K.R
Department of Plant Biotechnology, University of Agricultural Sciences, GKVK, Bangalore, India.

 

Ramachandra Kini
Department of Studies in Biotechnology, University of Mysore, Mysuru, India.

 

Kiran Kumar H.B.
NCBS, Affiliated to Nrupathunga University, India.

 

Please see the book here :- https://doi.org/10.9734/bpi/aodhr/v5/6178