In the present study, we have designed and synthesized a new
series of bipyrimidines by simple condensation and screened them for their in
vitro antimicrobial activities. Current research has depicted the efforts
towards the utilization of biphasic reaction systems in the synthesis of a
variety of heterocycles. This shows the remarkable importance of the monophasic
solvent system. A simple, green and efficient catalytic condensation process
has been developed to synthesize the series of 2-amino-6-substituted-
4,6-diphenyl-3',4,4',5-tetrahydro[4,5'-bipyrimidine]-2'(1H)-one (3a- j)
hybrids. The catalytic route was investigated efficiently in the presence of
NaY zeolite in an organic-aqueous (dichloromethane-water) solvent system. In
this method, biphasic solvent systems were explored for suitable applicability
where catalyst exhibits remarkable reactivity. The synthesized scaffolds of
bipyrimidines were studied as anti-microbial agents. The investigation of
antimicrobial screening data revealed that among 10 compounds screened,
compounds 3d, 3e, 3f and 3i demonstrated very good activity as compared to
standard drugs and the remaining compounds showed good to moderate inhibition
activities.
Synthesized compounds were screened for their in vitro
antibacterial activity against Staphylococcus aureus, E. coli and Pseudomonas
aurigenosa and also antifungal activity against the opportunistic pathogens
Candida albicans and Aspergillus niger.
Author(s) Details
Manisha S. Aswale
Department of Chemistry, Centre for Higher Learning and
Research, Sardar Patel Mahavidyalaya, Ganjward, Chandrapur-442402, India.
Raksha P. Dhankar
Department of Chemistry, Centre for Higher Learning and
Research, Sardar Patel Mahavidyalaya, Ganjward, Chandrapur-442402, India.
Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v3/8227E
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