Epigenetic modification refers to the reversible and
heritable changes in gene function under the condition of an unchanged gene
sequence, which primarily includes DNA methylation and histone modification. In
this review, we summarize the research progress of the N6-methyladenosine (m6A)
modification regulation mechanism in the central nervous system and discuss the
effects of gene expression regulation mediated by m6A modification on the
biological functions of neuropsychiatric disorders, thereby providing some
insight into new research targets and treatment directions for human diseases.
Epitranscriptomic modifications can affect every aspect of RNA biology,
including stability, transport, splicing, and translation, and participate in
global intracellular mRNA metabolism and regulation of gene expression and
various biological processes. M6A is the most prevalent RNA modification
contributing to normal embryonic brain development and memory formation. The
m6A modification is involved in the biological process of the central nervous
system by regulating neural-related mRNA expression. However, changes in the
level of m6A modification and the expression of its related proteins can cause
abnormal nervous system functions, including brain development retardation,
axon regeneration disorders, memory changes, and neural stem cell renewal and
differentiation disorders. Recent studies have revealed that m6A modification
and its related proteins play key roles in the development of various
neuropsychiatric disorders, such as depression, Alzheimer’s disease, and
Parkinson’s disease. Disruption of m6A modification in the brain can lead to
brain developmental delay and neuronal dysfunction. Future studies are needed to examine the overall
modification of m6A methylation and the joint effect of m6A methylation and
other transcriptomic factors.
Author(s) Details
Qingzhong Wang
Institute of Chinese Materia Medica, Shanghai University of
Traditional Chinese Medicine, Shanghai, 201203, China.
Yogesh Dwivedi
Department of Psychiatry and Behavioral Neurobiology,
University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA.
Please see the book here:- https://doi.org/10.9734/bpi/ibs/v4/7856C
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