A Novel Polyherbal Formulation- Sarkaraikolli Hastens Wound Healing Activity with Antidiabetic Potential | Chapter 3 | Pharmaceutical Science: New Insights and Developments Vol. 8

 

Diabetes is a chronic group of metabolic diseases characterised by the constantly elevated blood glucose levels, which leads to the glycation of body proteins, which may further cause serious complications. In recent years, the use of complementary medicine has seen significant growth, particularly in dietary interventions and traditional plant-based therapies derived from systems such as Ayurveda. No systematic studies have been reported for its wound healing and anti-diabetic properties of Sarkaraikolli. An effort has been made to establish the wound healing and anti-diabetic properties of the polyherbal formulation Sarkaraikolli. In this model, animals were administered with test and standard samples by the oral route. Frequently blood samples were taken and examined for blood glucose levels, which were assessed using a glucometer. The animals were sacrificed 2 hours on the 21st day after the treatment by cervical dislocation, and biochemical studies were performed. The blood samples were collected, and serum was separated by centrifugation at 3000 rpm for 15 minutes after a retro-orbital puncture. Different procedures were performed for the determination of liver enzyme tests. In the model of anti-diabetic animals were evenly divided into 5 groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4, and 5 were the treatment groups which were simultaneously treated with standard, 250 and 500 mg/kg extract respectively after glucose loading. Sarkaraikolli possesses significant anti-diabetic and wound healing activity when compared to the conventional medicine like Glibenclamide. Significant anti-diabetic action is visible due to lower blood glucose levels and maintenance of steady body weights. Sarkaraikolli wound healing activity is demonstrated by higher wound healing activity as compared to the standard medication. The biochemical parameters like SGOT, SGPT and ALP were determined by using the analytical kits. The results shown by the treatment of Sarkaraikolli were significant and are closer to the control group. This research work proved that Sarkaraikolli possesses significant anti-diabetic and wound-healing activity. When compared to conventional medicine, Glibenclamide, a significant anti-diabetic action is visible due to lower blood glucose levels and maintenance of steady body weights. Sarkaraikolli's wound healing activity is demonstrated by higher wound healing activity when compared to the standard drug (Nitrofurazone).

 

 

Author(s) Details

S. Sundar
Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada, Andhra Pradesh, India.

 

A. Bhavana
Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada, Andhra Pradesh, India.

 

N. K. S. Neeraja
Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada, Andhra Pradesh, India.

 

D. Prasanna
Department of Pharmaceutical Chemistry, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada, Andhra Pradesh, India.

 

R. Sunitha
Department of Pharmacognosy, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada, Andhra Pradesh, India.

 

 

Please see the book here:- https://doi.org/10.9734/bpi/psnid/v8/6122

Investigation on the Anti-ulcerogenic Effects and Anti-oxidative Properties of Ceiba pentandra Leaves on Alloxan-induced Diabetic Rats | Chapter 8 | Trends in Pharmaceutical Research and Development Vol. 5

 It has been shown that many natural products, mainly of plant origin, have promising practises that could help prevent and/or improve disease prevention. Gastric ulcer is a gastrointestinal tract ulceration arising from repeated erosions and stomach wall damage that can become perforated and develop into peritonitis and massive haemorrhage. Objectives: The current research aimed to assess the protective effects of Ceiba pentandra leaves methanol extract on gastric ulcers induced by indomethacin and ethanol and on oxidative stress indices of diabetic rats induced by alloxan. Location and length of study: Department of Biochemistry, University of Nigeria, Nsukka. Nature of the study: extraction and administration of graded doses of the extract. State of Enugu, Nigeria, from May, 2011 through October, 2011. Methodology: Ceiba pentandra leaves were extracted using methanol. For each of the ulcer experiments, 20 adult rats, split into five groups of four rats each, were used. In rats, gastric ulceration was caused by oral administration of indomethacin (50 mg / kg) and 95% ethanol (0.5 ml) thirty minutes after extract therapy and sacrificed to animals 8 hours later. Thirty (30) albino rats, divided into six (6) groups of five (5) rats each, were used for the diabetes research. Diabetes was induced by i.p. injection of alloxan monohydrate (150 mg / kg) for two weeks in overnight fasting animals and animals treated with a range of extract doses (100 , 200 and 400 mg / kg). For the determination of lipid profile and liver marker enzymes, serum obtained from the diabetic rats was used. Results: inhibition of severe and dose-dependent ulcers (70, 82 and 84 percent; 19, 53, and 58 percent for 100 , 200, and 400 mg / kg extracts, respectively) were developed for the ulcer models used in all extract-treated classes. Important reductions (p<0.05) were reported in fasting blood glucose, liver marker enzymes, total cholesterol, low density lipoprotein and triacylglycerides relative to those of the diabetes-untreated community in the serum of the extract-treated groups. Conclusion: The results of this study indicate that Ceiba pentandra leaves methanol extract has good anti-ulcerogenic and anti-oxidative properties and has the potential to be used as a herbal remedy for the treatment of gastrointestinal ulcers and diabetes control.

Author(s) Details

Dr. C. A. Anosike
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

S. C. Abugu
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

J. C. Ugwu
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

P. C. Ojeli
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

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