AKSS16-LIV01: An Antioxidant and Immunity-Boosting Multiherbal Formulation for Alcoholic Liver Dysfunction in Experimental Animal Model | Chapter 2 | Recent Developments in Chemistry and Biochemistry Research Vol. 5

 

High rates of alcohol intake are frequently the cause of liver complications. The majority of alcohol-drinking citizens in industrialized and developing nations suffer from cirrhosis, fatty liver, liver fibrosis, and even hepatocellular cancer, among other liver issues. Creating symptomatic, safe medication to go through this is a new global problem. The primary goal of the research is to provide a symptomatic, safe medicine to lessen liver damage caused by ethanol. We created a multi-herbal formulation (AKSS-16-LIV01), which may be helpful in liver complications.  In this investigation, we try to reduce liver damage from a variety of toxicants. Swiss albino mice were split up into seven groups, and each group was subjected to ethanol-induced injury for several weeks before our herbal preparation was used to investigate a healing response. The groups include the normal control group (Group-I), the group treated with 50% v/v ethanol (Group-II), the groups pre-treated with AKSS16-LIV01 at a low dose of 100 mg/kg/day (Group-III), the group pre-treated with AKSS16-LIV01 at a middle dose of 200 mg/kg/day (Group-IV), the group pre-treated with AKSS16-LIV01 at a high dose of 400 mg/kg/day (Group-V), the group pre-treated with Sylimarin at 100 mg/kg/day (Group-VI), and the only group treated with AKSS16-LIV01 (400 mg/kg/day) (Group-VII).In the mice given ethanol, the results showed a marked increase in a number of biochemical parameters, lipid profile parameters, lipid peroxidation, nitric oxide (NO) concentration, nitric oxide synthase level, and pro-inflammatory cytokines, such as tumour necrosis factor (TNF-\(\alpha\)) and transforming growth factor (TGF-\(\beta\)1). However, ethanol significantly decreased the levels of tissue antioxidant enzyme activity (SOD, CAT, GSH, and GPx), serum total protein, total albumin, albumin globulin ratio, and tissue total antioxidant enzyme activity. The formulation (AKSS16-LIV01) was applied therapeutically at a dose that determined its effectiveness in suppressing all relevant parameters mentioned above, while also shielding the liver from ethanol-induced fibrogenesis. In addition to this gross morphology of the liver, the hepato-protective impact of the formulation in comparison to the usual medication Sylimarin was clearly supported by H&E liver histology and Masson trichrome and serius red analysis of the liver sections. According to the study's findings, a multi-herbal formulation that was designed (AKSS16-LIV01) and given at a dose of 400 mg/kg/day produced the best possible response to lessen ethanol intoxication. The results unmistakably show that AKSS16-LIV01 may be a safe and non-toxic drug that shields the liver from oxidative damage caused by ethanol and keeps levels of pro-inflammatory cytokines stable over time.

 

Author(s) Details

Soumendra Darbar
Faculty of Science, Jadavpur University, Raja S C Mallick Road, Kolkata, West Bengal 700032, India.

Srimoyee Saha
Faculty of Science, Jadavpur University, Raja S C Mallick Road, Kolkata, West Bengal 700032, India.

Kausikisankar Pramanik
Faculty of Science, Jadavpur University, Raja S C Mallick Road, Kolkata, West Bengal 700032, India.

Atiskumar Chattopadhyay

Department of Health Science, Brainware University, 398, Ramkrishnapur Rd, Near Jagadighata Market, Barasat, Kolkata, West Bengal 700125, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v5/439

Pattern of Dyslipidemia among Prediabetics of Karnataka State, South India: A Cross Sectional Study |Chapter 4 | Medicine and Medical Research: New Perspectives Vol. 6

This study aims to explore the possibility of the existence of dyslipidemia among prediabetics in Karnataka state south India and to identify the risk factor(s) if any, for the onset of diabetes. Hyperglycemia can be determined by the glycated hemoglobin (HbA1c) value which indicates the blood glucose level over the past three months. A cross-sectional study involving 310 individuals in Bangalore, Karnataka State, South India from the period of February 2022 to March 2024 was considered for the study. Within the lipid profile, Total cholesterol (TC), High-Density Lipoprotein (HDL) and the ratio of TC to HDL displayed statistically significant differences between the means of the population of healthy nondiabetics and prediabetics. So, testing of TC, HDL and TC to HDL ratio at regular intervals for prediabetics should be made mandatory, as they fall in the risk category for developing type 2 Diabetes and this regular screening of TC,  HDL and TC to HDL ratio will prevent prediabetics from progressing into type2 diabetes later on. It is a well-known fact that the HbA1c level as a predicting factor differs among races and ethnicities as the rate of glycation and RBC life span differs among racial and ethnic groups. Regarding demographic factors, abdominal obesity was found to be statistically significantly associated with prediabetes. Prediabetics should implement a regular exercise regime to prevent themselves from becoming diabetics in their later years.

 

Author (s) Details

Rao Sujatha N
Department of Biochemistry, AECS Maruthi Dental College, Bangalore, Karnataka, India.

 

 

Please see the book here:- https://doi.org/10.9734/bpi/mmrnp/v6/2131

Effects of the Vita Slim and Green Tea as Anti-obesity Drugs on Certain Biochemical and Physiological Indices of Obese Adult Male Albino Rats | Chapter 9 | Recent Developments in Chemistry and Biochemistry Research Vol. 8

Background: A larger number and larger size of fat cells characterize obesity, a condition that has a detrimental effect on one's health. Because obesity is linked to an increased risk of diabetes and heart disease, the ideal anti-obesity medication would have weight loss that was long-lasting and had few side effects.

Objective: The objective of the study is to detect if the weight-loss drugs; green tea and Vita Slim negatively affect several biochemical and physiological markers.

Materials and Methods: This study utilized a total of twenty-one albino male rats (220±20 g). Rats were purchased from an animal unit of the Nile Pharmaceutical Company, Cairo, Egypt. Three groups consisted of 21 mature obese male albino rats (with a body weight of 220 ±20 gram): In Group one: control (vehicle treatment), in group two: for a period of 30 days, rats were given Vita slim (0.1mg/kg/day), and in group three: for 30 days, rats were given green tea (0.1 mg/kg/day).

Results: Significant changes were observed in the weight of the treated groups, in serum levels of AST/ALT, albumin, triglycerides, low-density lipoproteins (LDL), LDL/HDL ratio, urea, creatinine, as well as triiodothyronine (T3) as compared with the control group. It is proven that thyroid hormones, particularly T3, are important metabolic hormones. Energy generation is linked to the quantity of thyroid hormones in the bloodstream.

Conclusion: The study concluded that Vita Slim and green tea capsules have a deleterious influence on critical biochemical and physiological markers, notably liver functions. Several physiological and biochemical markers, including kidney and liver functions, have been shown to be negatively impacted by Vita Slim and green tea after 30 days of ingestion.

 

Author (s) Details

 

Eman G. E. Helal
Department of Zoology, Faculty of Science (Girls), Al-Azhar University, Egypt.

 

Nora A. AljalaudA
Biology Department, College of Science, Imam Abdulrahman Bin Faisal University, Saudi Arabia.

 

Ashraf M. M. Algendy
Department of Physiology, Faculty of Medicine (Boys), Al-Azhar University, Egypt.

 

Suzan S. Elpasty
Department of Zoology, Faculty of Science (Girls), Al-Azhar University, Egypt.

 

Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v8/2866

Evaluating the Impact of Glycemic Control, Lipid Derangement and Antioxidant Status on Progression of Diabetic Retinopathy | Chapter 11 | Achievements and Challenges of Medicine and Medical Science Vol. 8

Background: Diabetes Mellitus is a global health problem. It is a potentially life-threatening metabolic syndrome. There were nearly 171 million diabetics worldwide in 2000 with the number projected to be almost 2.5 times, about 366 million by the year 2030 (prevalence rate of 4.4%) with the greatest number of cases expected in China and India. Patients with diabetes show a difference in serum uric acid pattern in relation to the duration of the disease along with glycemic status, lipid derangements and complications associated with the disease.

Aims and Objectives: To study HbA1c levels to know the blood sugar levels for the past 3 months to assess the glycemic control and to estimate lipid profile to assess the risk of microvascular complications like Retinopathy in diabetic cases. Serum uric acid levels are estimated to evaluate its role in the pathophysiology of diabetes and to establish its association with glycemic control and lipid profile which helps to understand the onset and progression of complications such as retinopathy.

Materials and Methods: The present study consists of 75 cases of chronic diabetes with retinopathy as a complication in the age group of 45-75 years. The values of HbA1c, lipid profile and uric acid in cases are compared with that of 50 apparently healthy non-diabetics who are of the same age group. All the subjects were from the ophthalmology department of Govt. General Hospital, Kakinada and also from Nayana Eye Care Hospital, Kakinada.

Results: The Mean Values of HbA1C and lipid profile were significantly high in diabetic retinopathy cases (p<0.0001) as compared to the control group. The Mean values of uric acid in diabetic retinopathy cases do not show a significant difference from that of the control group (p=0.446).

Conclusion: The study shows that poor glycemic control plays a major role in the onset and progression of diabetic retinopathy. The significant changes in the lipid profile levels in diabetic retinopathy indicate lipid peroxidation plays a key role in the progression of the disease. Serum uric acid level has not shown statistically significant changes in diabetic retinopathy implying no role of uric acid in the progression of disease.

 

Author (s) Details

 

P. Usha Kiran
G. S. L. Medical College, Rajahmundry-533294, Andhra Pradesh, India.

 

B. Srinivasa Rao
Rangaraya Medical College, Kakinada-533003, Andhra Pradesh, India.

Please see the book here:- https://doi.org/10.9734/bpi/acmms/v8/3187

Association between Serum Ferritin and Some Bio Variables in Obese Male and Female at Obesity Medical Center in Iraq | Chapter 3 | Disease and Health: Research Developments Vol. 5

 

Obesity is a worldwide health complication. In 2014, 600 million adults and 42 million kids, less than five years of age, were obese. It is a hyperassembly of energy in the form of adipose tissues which has worse effects on health. The major factors of the obesity epidemic are: heavy meal which is rich in lipids, carbohydrates resulting in overweight and eventually obesity, and a decrease in physical activity that leads to defects in calorie conception. In health care facilities ferritin assay is used as a screening test to detect iron deficiency; however, its reliability in obesity has been questioned. The present study aimed to assess and compare the incidence of obesity, hyperferritinemia, hyperlipidemia, and hypouricemia among middle-aged hypertensive patients in the local setting and examined ferritin concentrations and other classical indices in obese males and females. Serum levels of ferritin was assessed using ELISA kit, while Hb was analyzed using Coulter LH 750 Hematology Analyzer and other parameters were assessed by colorimetric kits. This limited population study was conducted at the Obesity Medical Center at Al-Kindy Teaching Hospital, Baghdad, Iraq from January to March 2016. One hindered and eight patients were enrolled in this study plus to participate of 61 subjects as healthy control. Based on body mass index (BMI), 169 participants were divided into two groups: BMI ≥ 18.5–25 kg/m2 non obese (control), BMI ≥ 30 kg/m2 obese subjects. Patients with endocrine disease, pregnancy, and renal disease leading to hypertension were excluded from the study. The statistical package for the social sciences computer program version 20 (IBM SPSS Statistic software, IBM Corporation, New York, United States) was used for the analysis. The main demographic features data of the study population shows that systolic blood pressure and diastolic blood pressure were raised significantly in obese patients (P<0.05) compared with control. Serum hemoglobin levels were decreased significantly in obese males when compared with the non-obese group and no difference in the female group was observed. In addition, the levels of lipid profile and other studied parameters according to gender showed the following results:- significant elevation in TG, LDL, VLDL, glucose, and ferritin in the obese (for both genders) compared with the non-obese group. A significant decrease was noticed in HDL-c, uric acid, and urea levels in the obsessed group compared with the non-obese group in both genders. The comparison results between obese males and females concluded that a significant elevation in BMI with a significant decrease in VLDL and ferritin levels in obese females compared with obese males. The present study examines all types of correlations between parameters. In obese patients (n=108), stepwise linear regression analysis showed that serum ferritin levels were independently correlated with LDL, VLDL levels, and age, (P< 0.001). Increased BMI and ferritin levels are more frequent in females as compared to male obese patients which are an important risk factor for obesity complications.

Author (s) Details

 

Zaizafoon N. Nasif
Department of Chemistry, Collage of Science, Mustansiriyah University, Baghdad, Iraq.

Emad M. Eltayef
Department of Chemistry, Collage of Science, Mustansiriyah University, Baghdad, Iraq.

 

Nasser M. Al-Janabi
Department of Soil, Collage of Agriculture, University of Kufa, Iraq.

 

Ali N. Niseaf
Department of Chemistry, Collage of Applied Science (Ibn Al-Haitham), University of Baghdad, Iraq.

 

Please see the book here:- https://doi.org/10.9734/bpi/dhrd/v5/4065

Effect of Habitual Consumption of Madhuca longifolia Drinks on Diabetes and Dyslipidemia among Santhal Tribals | Chapter 3 | Advanced Concepts in Pharmaceutical Research Vol. 4

 This affiliate aims to investigate the Effect of usual consumption of Madhuca longifolia drinks on diabetes and dyslipidemia with santhal tribals. Madhuca longifolia (mahua) is a tropical tree extensive throughout India, generally on plains.  By way of its abundant therapeutic benefits, the tree is visualized as a godsend by tribals the one live in the woodland.  Further studies proved that advantageous effects are observed in Santhals many of whom are balanced consumers of Madhuca longifolia drinks. The authors still did a study on this facet.Diabetes and lipid profiles of ancestry, as well as normal anthropometric parameters, were assessed in a Santhal family population (only men were recruited), many of whom, but not all, are established mahua drink consumers. The results were statistically resolved and compared using the undergraduate's t-test, and conclusions were attained.The results demonstrate that anthropometric measures do not vary much, but FBS does. HbA1c, cholesterol, and LDL cholesterol levels are reduced with mahua consumers compared to non-shoppers. When compared to the additional group, mahua consumers have bigger HDL levels. In the case of VLDL and triglycerides, no significant effect was discovered.The research found that common mahua drinks among the Santhal tribe enhanced diabetes and lipid profiles, other than triglycerides and VLDL.  More extensive research is necessary to get correct insight and practical benefits concerning this.

Author(s) Details:

Ayan Pal,
Department of Pharmacology, M.G.M. Medical College and L.S.K. Hospital, Kishanganj, Bihar, India.

Arunima Datta,
Department of Physiology, M.G.M. Medical College and L.S.K. Hospital, Kishanganj, Bihar, India.

Please see the link here: https://stm.bookpi.org/ACPR-V4/article/view/12924

Effects of Gestational Hypertriglyceridemia: A Rare Case of Pink Blood Conundrum during Pregnancy | Chapter 9 | Advanced Concepts in Medicine and Medical Research Vol. 7

 The aims and aims of the chapter are to recognize the effects of Hypertriglyceridemia before birth. Gestation hypertriglyceridemia is one of the exceptional diseases that can construct sequential derangement in the lipid create a likeness in a picture of the  pregnant mothers. A young woman has been picked to examine the impact of Hypertriglyceridemia on her gestation. She developed Gestational hypertriglyceridemia due to assumptive obesity and diabetes that was accidentally found all the while cesarean section, and luckily successful feto-maternal effect afterwards. It is owned by screen the high-risk patient on booking for chances of cultivating Hypertriglyceridemia later in pregnancy to prevent all the complications.

Author(s) Details:

Ayesha Shahid,
Shaikh Zayed Hospital, Lahore, Pakistan.

Amna Javed,
Shaikh Zayed Hospital, Lahore, Pakistan.

Fatima Chaudhry,
Department of Gynecology and Obstetrics, Shaikh Zayed Hospital, Lahore, Pakistan.

Muhammad Ikram,
Shaikh Zayed Hospital, Lahore, Pakistan.

Rukiya Tariq,
University of the Punjab, Pakistan.

Sana Danish,
Shaikh Zayed Hospital, Lahore, Pakistan.

Please see the link here: https://stm.bookpi.org/ACMMR-V7/article/view/12692

Association of Atherogenic Index and Oxidized-LDL as a Strong Independent Risk Predictor of CHD in Young Smokers | Chapter 2 | Research Highlights in Disease and Health Research Vol. 7

 Introduction: smoke smoking is an incidental risk factor for heart failure and induces changes in lipid profile apiece oxidation of lipids, specifically LDL. Hence the need for determine ox-LDL and allure association accompanying atherogenic indices in the risk of cardiovascular risk. The study proposed to determine oxidized-LDL and atherogenic indications in relation to smoke smokers.Methods:  This case-control study included 240 things in which smoke smokers were (n=120) and were compared accompanying (n=120) non-smokers. The ox-LDL, APO-A1, and APO-B were performed utilizing Enzyme-linked Immune Sorbent Assay (ELISA) and atherogenic risk percentages were calculated.Results: The study shows that ox-LDL was a considerably increased in smokers and too significant increase in TC, TGL, and LDL was noticed. When compared to nonsmokers, smokers had significantly higher atherogenic risk indications. Pearson correlation tests disclosed that ox-LDL and AIP were substantially and absolutely linked accompanying non-HDL, CRI- Castelli's risk Index-I, CRII- Castelli's risk Index-II, AC-Atherogenic Coefficient, CI-Cholindex, and APO-B- Apolipoprotein B (p<0.001). And was inversely guide APO-A1 and HDL-C (p<0.001). The unadjusted odds percentages for ox-LDL and AIP in the univariate logistic regression study were 1.861 (95% confidence pause: 1.347-2.375), p<0.001, and 1.782 (95% confidence break: 1.490-2.131), P.001), respectively. Multivariate logistic reversion analysis manifested that ox-LDL and AIP were independent risk determinants for CHD in young smokers.Conclusion: In smokers, ox-LDL and atherogenic indices give the impression strong free risk predictors for CHD than conventional lipid limits..

Author(s) Details:

Meera Shivasekar,
Department of Biochemistry, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulthur, Tamil Nadu, PIN: 603203, India.

Dinesh Nath,
Department of Biochemistry, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulthur, Tamil Nadu, PIN: 603203, India.

V. M. Vinodhini,
Department of Biochemistry, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulthur, Tamil Nadu, PIN: 603203, India.

Please see the link here: https://stm.bookpi.org/RHDHR-V7/article/view/10566Z

Identification of Dyslipidemia in Children and Adolescents: The Slovak Lipid Community Study| Chapter 4 | Current Topics on Chemistry and Biochemistry Vol. 8

 Objective: The aim concerning this study search out estimate remark values for lipid sketch of Slovak pediatric populace to advance the labeling of offsprings with dyslipidemia.Methods: A total of 873 athletic infants old 7-18 age (55% guys) were included in the cross-divided Slovak Lipid Community Study. Fasting ancestry samples were calm and standard lipid processes for total cholesterol (TC), depressed-bulk lipoprotein cholesterol (LDL-C), high-bulk lipoprotein cholesterol (HDL-C) and triglycerides (TG) were secondhand. Smoothed citation lines and percentiles (5th, 10th, 25th, 50th, 75th, 90th, and 95th) were create utilizing LMS method.Results: All lipid limits except that TC and LDL-C in schoolgirls were larger in adolescence than in adolescence, and movement lipid levels frequently varied 'tween common with fermenting. At the age of 17-18 age, 6% of children and 15% of schoolgirls had atypical TC levels whereas strange TG levels bestowed 11% of fellows and 13% of young women. Abnormal depressed HDL-C levels were noticed in 17% of boys and 10% of daughters.Conclusions: The results concerning this study desire that age and neuter, in pediatric populace, play an important duty for lipid sketch judgment. In addition, supposed age- and grammatical rules applying to nouns that connote sex or animateness-based remark cut points for antitoxin lipids grant permission help labeling of children accompanying dyslipidemia.

Author(s) Details:

Roman Alberty,
Department of Biology and Ecology, Matej Bel University, Banská Bystrica, Slovakia.

Dáša Albertyová,
Department of Clinical Biochemistry, F. D. Roosevelt Hospital, Banská Bystrica, Slovakia.

Please see the link here: https://stm.bookpi.org/CTCB-V8/article/view/9347

Determination of Lipid Profile and Atherogenic Indices for Cardiovascular Disease Risk Based on Different Fish Consumption Habits| Chapter 7 | Challenges and Advances in Pharmaceutical Research Vol.1

The ingestion of moderate amounts of fish on a regular basis is linked to a lower risk of death from cardiovascular disease (CVD). However, due to the oxidation susceptibility of the polyunsaturated fatty acids in fish, the positive effects of a fish-enriched diet appear to be paradoxical. The atherogenic index is a useful measure for identifying patients who are at risk for cardiovascular disease. Certain fish dietary habits have a positive effect on lipid profile levels, lowering the risk of coronary heart disease. The goal of this study was to assess CVD risk using atherogenic indices and to examine the plasma lipid profile of healthy persons with various fish intake habits.

Methods: Healthy people's fasting blood samples were taken for lipid profile calculations using an automated analyzer. Each participant provided detailed information on their physical and atherogenic characteristics.

Conclusions: The CVD risk profiles varied depending on the type of fish consumed. Total cholesterol, triglyceride (TG), and non-high-density lipoprotein (Non-HDL-C) levels differed substantially (p0.05), whereas high-density lipoprotein cholesterol levels differed considerably (p0.001). Inland fish consumers had a higher level of TG/HDL. The atherogenic coefficient and the Castelli risk index-2, on the other hand, did not differ significantly depending on the type of fish consumed. All fish eaters, including beef eaters, had atherogenic indices that were borderline "high risk."

Conclusion: People who ate fish and beef were at a higher risk than those who ate inland and sea fish. Non-HDL cholesterol may be a marker for a lipid profile in the blood linked to an elevated risk of heart disease. Non-HDL-C levels were borderline high risk for CVD in all fish, including beef eaters. There were age and sex-related differences in the TC and lipid-protein fractions. TC and LDL-C values were greater in women than in men. Non-HDL-C and TG/HDL-C levels can be utilised as more accurate indicators of CVD risk.

Author(s) Details:

Chandravathani Devadawson,
Department of Zoology, Faculty of Science, Eastern University, Chenkalady, Sri Lanka.



Chamila Jayasinghe,
Department of Food Science and Technology, Faculty of Livestock, Fisheries and Nutrition, Wayamba University of Sri Lanka, Makandura, Gonawila, Sri Lanka.



Sivakanesan Ramiah,
Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Sri Lanka.

Arulnithy Kanagasingam,
Cardiologist Unit, Teaching Hospital, Batticaloa, Sri Lanka.

Please see the link here: https://stm.bookpi.org/CAPR-V1/article/view/6238

Raja Yoga Meditation in Glycaemic Status in Type 2 Diabetes Mellitus | Chapter 2 | Highlights on Medicine and Medical Science Vol. 14

 In today's world, stress affects the majority of people, either directly or indirectly. Stress, whether physical, emotional, or psychological, has gotten a lot of attention in recent years as a cause or exacerbating factor for numerous diseases such as diabetes, hyperthyroidism or hypothyroidism, Cushing's disease, and so on. Meditation is a simple behavioural intervention that anyone of any age or physical condition may learn and practise. Meditation has been shown to modify autonomic regulation of homeostatic systems, as well as have favourable physiological consequences. A cross-sectional study was undertaken on 60 patients with Type 2 diabetes mellitus, 30 of whom had been practising Raja Yoga meditation for more than 5 years and 30 of whom had not. Meditation practitioners had significantly lower blood glucose and glycated haemoglobin levels. Practitioners of meditation also had lower lipid profiles, total cholesterol, and serum triglycerides. As a result, we discovered that meditation helps to preserve autonomic balance in people with type 2 diabetes.

Author (S) Details

Mrunal Phatak
Department of Physiology, AIIMS, Nagpur, India.

Tara Chawla
Department of Physiology, IGGMC, Nagpur, India.

Pallavi Phatak
Department of Surgery, Dy Patil Medical College, Kolhapur, India.

View Book :- https://stm.bookpi.org/HMMS-V14/article/view/2553

Investigation on the Anti-ulcerogenic Effects and Anti-oxidative Properties of Ceiba pentandra Leaves on Alloxan-induced Diabetic Rats | Chapter 8 | Trends in Pharmaceutical Research and Development Vol. 5

 It has been shown that many natural products, mainly of plant origin, have promising practises that could help prevent and/or improve disease prevention. Gastric ulcer is a gastrointestinal tract ulceration arising from repeated erosions and stomach wall damage that can become perforated and develop into peritonitis and massive haemorrhage. Objectives: The current research aimed to assess the protective effects of Ceiba pentandra leaves methanol extract on gastric ulcers induced by indomethacin and ethanol and on oxidative stress indices of diabetic rats induced by alloxan. Location and length of study: Department of Biochemistry, University of Nigeria, Nsukka. Nature of the study: extraction and administration of graded doses of the extract. State of Enugu, Nigeria, from May, 2011 through October, 2011. Methodology: Ceiba pentandra leaves were extracted using methanol. For each of the ulcer experiments, 20 adult rats, split into five groups of four rats each, were used. In rats, gastric ulceration was caused by oral administration of indomethacin (50 mg / kg) and 95% ethanol (0.5 ml) thirty minutes after extract therapy and sacrificed to animals 8 hours later. Thirty (30) albino rats, divided into six (6) groups of five (5) rats each, were used for the diabetes research. Diabetes was induced by i.p. injection of alloxan monohydrate (150 mg / kg) for two weeks in overnight fasting animals and animals treated with a range of extract doses (100 , 200 and 400 mg / kg). For the determination of lipid profile and liver marker enzymes, serum obtained from the diabetic rats was used. Results: inhibition of severe and dose-dependent ulcers (70, 82 and 84 percent; 19, 53, and 58 percent for 100 , 200, and 400 mg / kg extracts, respectively) were developed for the ulcer models used in all extract-treated classes. Important reductions (p<0.05) were reported in fasting blood glucose, liver marker enzymes, total cholesterol, low density lipoprotein and triacylglycerides relative to those of the diabetes-untreated community in the serum of the extract-treated groups. Conclusion: The results of this study indicate that Ceiba pentandra leaves methanol extract has good anti-ulcerogenic and anti-oxidative properties and has the potential to be used as a herbal remedy for the treatment of gastrointestinal ulcers and diabetes control.

Author(s) Details

Dr. C. A. Anosike
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

S. C. Abugu
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

J. C. Ugwu
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

P. C. Ojeli
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/303