Background: Diabetes Mellitus is a global health problem. It is a potentially life-threatening metabolic syndrome. There were nearly 171 million diabetics worldwide in 2000 with the number projected to be almost 2.5 times, about 366 million by the year 2030 (prevalence rate of 4.4%) with the greatest number of cases expected in China and India. Patients with diabetes show a difference in serum uric acid pattern in relation to the duration of the disease along with glycemic status, lipid derangements and complications associated with the disease.
Aims and Objectives: To study HbA1c levels to know the blood sugar
levels for the past 3 months to assess the glycemic control and to estimate
lipid profile to assess the risk of microvascular complications like Retinopathy
in diabetic cases. Serum uric acid levels are estimated to evaluate its role in
the pathophysiology of diabetes and to establish its association with glycemic
control and lipid profile which helps to understand the onset and progression
of complications such as retinopathy.
Materials and Methods: The present study consists of 75 cases of
chronic diabetes with retinopathy as a complication in the age group of 45-75
years. The values of HbA1c, lipid profile and uric acid in cases are compared
with that of 50 apparently healthy non-diabetics who are of the same age group.
All the subjects were from the ophthalmology department of Govt. General
Hospital, Kakinada and also from Nayana Eye Care Hospital, Kakinada.
Results: The Mean Values of HbA1C and lipid profile were
significantly high in diabetic retinopathy cases (p<0.0001) as compared to
the control group. The Mean values of uric acid in diabetic retinopathy cases
do not show a significant difference from that of the control group (p=0.446).
Conclusion: The study shows that poor glycemic control plays a
major role in the onset and progression of diabetic retinopathy. The
significant changes in the lipid profile levels in diabetic retinopathy
indicate lipid peroxidation plays a key role in the progression of the disease.
Serum uric acid level has not shown statistically significant changes in
diabetic retinopathy implying no role of uric acid in the progression of
disease.
Author (s) Details
P. Usha Kiran
G. S. L. Medical College, Rajahmundry-533294, Andhra Pradesh,
India.
B. Srinivasa Rao
Rangaraya Medical College, Kakinada-533003, Andhra Pradesh, India.
Please see the book here:- https://doi.org/10.9734/bpi/acmms/v8/3187
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