Wednesday, 26 March 2025

Valproic Acid and Stevens-Johnson Syndrome: A Vital Warning for Patient Safety | Chapter 10 | Disease and Health Research: New Insights Vol. 10

 Stevens-Johnson Syndrome is a severe condition that affects the skin and mucous membranes, often caused by medications or infections. Early diagnosis and treatment are crucial for improving outcomes and preventing lasting damage. This case study details the experience of a three-year-old boy who developed SJS after beginning valproate treatment for seizure management following a traumatic brain injury. Initially, he showed fever, facial redness, and a runny nose, which progressed to a severe rash and blisters. The patient is a known case of traumatic brain injury fall from the fifth floor in September 2022— developed seizures after acquired brain injury fall. A dermatologist confirmed the diagnosis of SJS linked to valproate. Swift diagnosis, discontinuation of the offending drug, and supportive care are essential in managing SJS such as IV fluids, wound management, and preventing serious complications. Early intervention and comprehensive care from various medical professionals are crucial for improving patient outcomes. Further research and awareness are essential to understand better the risk factors and mechanisms underlying drug-induced SJS and to improve prevention and treatment strategies.

 

Author (s) Details

Jafrin Sadiq Abdul Razack
Thumbay University Hospital, Ajman, United Arab Emirates.

 

Syeda Juveria Hussaini
Thumbay University Hospital, Ajman, United Arab Emirates.

 

Saud Khaled Aldoseri
Bahrain Defense Force Hospital, Bahrain.


Hisham Abubacker Musthafa
Gulf Medical University, Ajman, United Arab Emirates.

Antony Calvin Ossanam
Gulf Medical University, Ajman, United Arab Emirates.

 

Ibtisam Akram
Gulf Medical University, Ajman, United Arab Emirates.

 

Sahil Asgar Ali
Prime Hospital, Dubai, United Arab Emirates.

Ajimal Sainul
Thumbay University Hospital, Ajman, United Arab Emirates.

 

Vivek Karan
Prime Hospital, Dubai, United Arab Emirates.

 

Please see the book here:- https://doi.org/10.9734/bpi/dhrni/v10/3208

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