Valproic Acid and Stevens-Johnson Syndrome: A Vital Warning for Patient Safety | Chapter 10 | Disease and Health Research: New Insights Vol. 10

 Stevens-Johnson Syndrome is a severe condition that affects the skin and mucous membranes, often caused by medications or infections. Early diagnosis and treatment are crucial for improving outcomes and preventing lasting damage. This case study details the experience of a three-year-old boy who developed SJS after beginning valproate treatment for seizure management following a traumatic brain injury. Initially, he showed fever, facial redness, and a runny nose, which progressed to a severe rash and blisters. The patient is a known case of traumatic brain injury fall from the fifth floor in September 2022— developed seizures after acquired brain injury fall. A dermatologist confirmed the diagnosis of SJS linked to valproate. Swift diagnosis, discontinuation of the offending drug, and supportive care are essential in managing SJS such as IV fluids, wound management, and preventing serious complications. Early intervention and comprehensive care from various medical professionals are crucial for improving patient outcomes. Further research and awareness are essential to understand better the risk factors and mechanisms underlying drug-induced SJS and to improve prevention and treatment strategies.

 

Author (s) Details

Jafrin Sadiq Abdul Razack
Thumbay University Hospital, Ajman, United Arab Emirates.

 

Syeda Juveria Hussaini
Thumbay University Hospital, Ajman, United Arab Emirates.

 

Saud Khaled Aldoseri
Bahrain Defense Force Hospital, Bahrain.

Hisham Abubacker Musthafa
Gulf Medical University, Ajman, United Arab Emirates.

Antony Calvin Ossanam
Gulf Medical University, Ajman, United Arab Emirates.

 

Ibtisam Akram
Gulf Medical University, Ajman, United Arab Emirates.

 

Sahil Asgar Ali
Prime Hospital, Dubai, United Arab Emirates.

Ajimal Sainul
Thumbay University Hospital, Ajman, United Arab Emirates.

 

Vivek Karan
Prime Hospital, Dubai, United Arab Emirates.

 

Please see the book here:- https://doi.org/10.9734/bpi/dhrni/v10/3208

Disorders in Urinary Sphincter of Neurological Origin: A Prognostic Aspects | Chapter 8 | Current Progress in Medicine and Medical Research Vol. 2

 This unit evaluated  the prognosis of urinary sphincter disorders all the while neurological environments. Complications of Urinary sphincter disorders of neurological origin maybe life threatening. The usual micturition process requires the decent function of both the bladder and urethral sphincters. Normal service of the detrusor muscle and a physiologically competent within and external urethral sphincter should to maintain healthy urinary performance and continence.We conducted an examining, prospective study for a ending of six (6) months from January 6 to June 6, 2020 in the neurology department of the Ignace Deen National Hospital in Conakry. A total of 1081 cases were selected among whom, 324 bestowed (TSUON), that is to voice a frequency of 30%, which worried subjects aged 57.3±16.4 age with a slight female reign 50.3%. Urinary incontinence (80.6%) was associated with confusions such as urinary tract contamination with a extreme proportion of cerebral damage (92.3%). The study demonstrated that urinary incontinence was the most average reason for consultation. HIV contamination (P=0.015), bedsores (P=0.049), and inhalation pneumonia (P=0.001) were the main poor prognostic determinants.Urinery sphincter abnormalities are components of a remote possibility, both lively and functional, in elderly victims with excretion incontinence.The factors doing the regression were human immunodeficiency virus (HIV) contamination, pressure sores and breathing pneumonitis.

Author(s) Details:

Bangoura Mohamed Asmaou,

Neurology Department, CHU in Conakry, Guinea.

Please see the link here: https://stm.bookpi.org/CPMMR-V2/article/view/11288