Background: Apelin is an adipokine that plays an important role in the prediction of early Type II Diabetes Mellitus (T2DM). Only a few studies on the role of apelin in T2 D M are available, so this work on apelin was conducted to establish the connection between apelin and Oxidized Low-Density Lipoprotein (ox-LDL) in risk prediction of CHD inT2DM.
Objective: The aim of the study is to assess the association of
serum apelin with ox-LDL in Type 2 Diabetes Mellitus patients and correlate the
result with Insulin resistance and lipid profile
Materials and Methods: The study included 60 patients and was
equally divided into Group I (30 controls) and Group II (30 T2DM patients).
Body Mass Index (BMI), Fasting Blood Glucose (FBG), HbA1C, insulin, lipid
profile, ox-LDL, creatinine, and apelin were analyzed.
Results: FBG, HbA1C, and HOMA-IR were higher in Group II than in
Group I (p<0.001). Although the apelin levels were significantly higher in
Group II compared to Group I. The ox-LDL was found to be significantly elevated
in Group II compared to Group I, and Apelin/ox-LDL was also significantly elevated
in Group II. Pearson correlation analysis revealed that serum apelin correlated
with ox-LDL in Group II (r = 0.697).
Conclusion: The study concludes that increased serum apelin along
with ox- LDL might have significant clinical use as a marker of cardiovascular
risk in T2DM. Apelin serves as an independent predictor, increasing the
potential of the possible relation between apelin and ox-LDL in the
pathogenesis of CHD risk in type 2 diabetes mellitus.
Author
(s) Details
Meera Shivasekar
Department of Biochemistry, SRM Medical College Hospital and Research
Centre, SRMIST, Kattankulthur, Tamil Nadu, India.
Devika S
Department of Biochemistry, SRM Medical College Hospital and Research
Centre, SRMIST, Kattankulthur, Tamil Nadu, India.
Nayana Mathew
Department of Biochemistry, SRM Medical College Hospital and Research
Centre, SRMIST, Kattankulthur, Tamil Nadu, India.
V. M. Vinodhini
Department of Biochemistry, SRM Medical College Hospital and Research
Centre, SRMIST, Kattankulthur, Tamil Nadu, India.
Please see the book here:- https://doi.org/10.9734/bpi/acmms/v4/3103
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