Investigating the Gastro Protective Effects of Tadalafil on Ethanol- Induced and Reserpine –Induced Gastric Ulcer in Rats | Chapter 9 | Research Developments in Medicine and Medical Science Vol. 9

 This study examined the potential of tadalafil which is secondhand in the management of erectile dysfunction on intoxicating- induced and reserpine –inferred gastric abscess in rats. Gastric ulcer is a prevalent affliction with miscellaneous etiologies, including non-steroidal antagonistic-inflammatory drugs and alcohol devouring. Drug repurposing is a system by which drugs already common are redirected for another therapeutic use. Tadalafil is PDE5 inhibitors. Cialis® that contain 20mg of tadalafil was secondhand. Male rats weighing 180 -252g were verbally administered 95% Ethanol at 1ml/200g of rats to induce stomachic ulcer at 1h post tadalafil presidency. In another group, 5mg/ml of Reserpine in 0.5% acetic acid was executed to rats to induce gastric lesion, also at 1h post tadalafil presidency. Omeprazole was used as standard drugs. After 4h, stomach tissues were detached and assessed for Ulcer Index and Protective ratio. 50mg/kg of tadalafil shown a significant decline in Ulcer Index in reserpine-induced and flammable liquid-induced models when compared to standard. Tadalafil has gastro securing potential at lower concentration. This study is clinically appropriate because it gives clinicians better healing information on the best drugs for ulcer situation as well as awareness and alternative therapy for managing pertaining to the stomach ulcers. Pharmaceutical firms may further start to consider combining tadalafil accompanying ulcer procedures, particularly for sterility-affected in men.

Author(s) Details:

Doris N. Ajibo,
Department of Experimental Pharmacology and Toxicology, Faculty of Pharmacy, University of Port Harcourt, P.M.B. 5323, Choba, Rivers State, Nigeria.

Udeme O. Georgewill,
Department of Pharmacology, Faculty of Basic Clinical Sciences, University of Port Harcourt, P.M.B. 5323, Choba, Rivers State, Nigeria.

Owunari A. Georgewill,
Department of Pharmacology, Faculty of Basic Clinical Sciences, University of Port Harcourt, P.M.B. 5323, Choba, Rivers State, Nigeria.

Please see the link here: https://stm.bookpi.org/RDMMS-V9/article/view/10361

Research on Gastric Ulcer Model in Mini-Pig |Chapter 9 | Current Research in Agriculture and Veterinary Sciences Vol. 3

 The mini-pig has been in high demand in the basic and clinical research fields due to its ease of handling, small size, and analytical and physiological similarities to humans. It has been used in numerous clinical studies to mimic a variety of diseases, including cardiovascular disease, diabetes, metabolic syndrome, bone abnormalities, skin infections, and gastrointestinal ailments. It has the potential to be the most useful animal model for studying gastrointestinal diseases such as gastric ulcers. Materials and Procedures: Sus scrofa female mini-pigs weighing around 30 kg were used in this experiment. After a week of acclimation, the animals were fasted for 48 hours with free access to drinking water, followed by an endoscopic intra-gastric acetic acid injection. Mini-pigs were divided into two groups. It has the potential to be the most useful animal model for studying gastrointestinal diseases such as gastric ulcers. Materials and Procedures: Sus scrofa female mini-pigs weighing around 30 kg were used in this experiment. After a week of acclimation, the animals were fasted for 48 hours with free access to drinking water, followed by an endoscopic intra-gastric acetic acid injection. Mini-pigs were divided into two groups. two groups of two mini-pigs each Endoscopy was used to investigate the process of gastric ulcer development at the time of injection, on the 7th and 14th days. An autopsy was performed 14 days after the drug injection, followed by a stomach tissue analysis. Gastric ulcer was successfully induced in mini-pig animals, with clearly visible signs of necrosis, inflammation, and mineralization. Famotidine's therapeutic properties were demonstrated when illness symptoms were significantly reduced. Conclusion: We discovered that mini-pigs, which have a high resemblance to humans, can be an effective and practical species for inducing gastric ulcers and can be used in a variety of preclinical research. The use of animal models in the study of digestive diseases is critical for understanding the pathogenesis of these disorders and testing new therapies.

Author(s) Details

Woon Kyu Lee
Department of Biomedical Sciences, School of Medicine, Inha University, Incheon, South Korea.

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Investigation on the Anti-ulcerogenic Effects and Anti-oxidative Properties of Ceiba pentandra Leaves on Alloxan-induced Diabetic Rats | Chapter 8 | Trends in Pharmaceutical Research and Development Vol. 5

 It has been shown that many natural products, mainly of plant origin, have promising practises that could help prevent and/or improve disease prevention. Gastric ulcer is a gastrointestinal tract ulceration arising from repeated erosions and stomach wall damage that can become perforated and develop into peritonitis and massive haemorrhage. Objectives: The current research aimed to assess the protective effects of Ceiba pentandra leaves methanol extract on gastric ulcers induced by indomethacin and ethanol and on oxidative stress indices of diabetic rats induced by alloxan. Location and length of study: Department of Biochemistry, University of Nigeria, Nsukka. Nature of the study: extraction and administration of graded doses of the extract. State of Enugu, Nigeria, from May, 2011 through October, 2011. Methodology: Ceiba pentandra leaves were extracted using methanol. For each of the ulcer experiments, 20 adult rats, split into five groups of four rats each, were used. In rats, gastric ulceration was caused by oral administration of indomethacin (50 mg / kg) and 95% ethanol (0.5 ml) thirty minutes after extract therapy and sacrificed to animals 8 hours later. Thirty (30) albino rats, divided into six (6) groups of five (5) rats each, were used for the diabetes research. Diabetes was induced by i.p. injection of alloxan monohydrate (150 mg / kg) for two weeks in overnight fasting animals and animals treated with a range of extract doses (100 , 200 and 400 mg / kg). For the determination of lipid profile and liver marker enzymes, serum obtained from the diabetic rats was used. Results: inhibition of severe and dose-dependent ulcers (70, 82 and 84 percent; 19, 53, and 58 percent for 100 , 200, and 400 mg / kg extracts, respectively) were developed for the ulcer models used in all extract-treated classes. Important reductions (p<0.05) were reported in fasting blood glucose, liver marker enzymes, total cholesterol, low density lipoprotein and triacylglycerides relative to those of the diabetes-untreated community in the serum of the extract-treated groups. Conclusion: The results of this study indicate that Ceiba pentandra leaves methanol extract has good anti-ulcerogenic and anti-oxidative properties and has the potential to be used as a herbal remedy for the treatment of gastrointestinal ulcers and diabetes control.

Author(s) Details

Dr. C. A. Anosike
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

S. C. Abugu
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

J. C. Ugwu
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

P. C. Ojeli
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

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