Investigating the Gastro Protective Effects of Tadalafil on Ethanol- Induced and Reserpine –Induced Gastric Ulcer in Rats | Chapter 9 | Research Developments in Medicine and Medical Science Vol. 9

 This study examined the potential of tadalafil which is secondhand in the management of erectile dysfunction on intoxicating- induced and reserpine –inferred gastric abscess in rats. Gastric ulcer is a prevalent affliction with miscellaneous etiologies, including non-steroidal antagonistic-inflammatory drugs and alcohol devouring. Drug repurposing is a system by which drugs already common are redirected for another therapeutic use. Tadalafil is PDE5 inhibitors. Cialis® that contain 20mg of tadalafil was secondhand. Male rats weighing 180 -252g were verbally administered 95% Ethanol at 1ml/200g of rats to induce stomachic ulcer at 1h post tadalafil presidency. In another group, 5mg/ml of Reserpine in 0.5% acetic acid was executed to rats to induce gastric lesion, also at 1h post tadalafil presidency. Omeprazole was used as standard drugs. After 4h, stomach tissues were detached and assessed for Ulcer Index and Protective ratio. 50mg/kg of tadalafil shown a significant decline in Ulcer Index in reserpine-induced and flammable liquid-induced models when compared to standard. Tadalafil has gastro securing potential at lower concentration. This study is clinically appropriate because it gives clinicians better healing information on the best drugs for ulcer situation as well as awareness and alternative therapy for managing pertaining to the stomach ulcers. Pharmaceutical firms may further start to consider combining tadalafil accompanying ulcer procedures, particularly for sterility-affected in men.

Author(s) Details:

Doris N. Ajibo,
Department of Experimental Pharmacology and Toxicology, Faculty of Pharmacy, University of Port Harcourt, P.M.B. 5323, Choba, Rivers State, Nigeria.

Udeme O. Georgewill,
Department of Pharmacology, Faculty of Basic Clinical Sciences, University of Port Harcourt, P.M.B. 5323, Choba, Rivers State, Nigeria.

Owunari A. Georgewill,
Department of Pharmacology, Faculty of Basic Clinical Sciences, University of Port Harcourt, P.M.B. 5323, Choba, Rivers State, Nigeria.

Please see the link here: https://stm.bookpi.org/RDMMS-V9/article/view/10361

Medical Expulsive Therapy of Distal Ureteric Stones: A Comparative Study of Tadalafil vs Tamsulosin | Chapter 23 | Issues and Developments in Medicine and Medical Research Vol. 9

 Background: The care of patients with ureteral calculi has changed dramatically in recent years, with the conservative approach becoming the predominant focus, with the main advantage being reduced patient morbidity. Adjuvant medical expulsive therapy (MET) can be used in conjunction with the expectant method for distal ureteric stones to help with symptom relief and stone evacuation. By comparing Tadalafil and Tamsulosin, the current study aimed to find the single best monotherapy for medical expulsive therapy of distal ureteric stones.

A hospital-based comparison study was conducted at the Department of Surgery of a tertiary care hospital. A total of 120 cases with lower ureteric calculus were included in the investigation. These 120 patients were then separated into two groups of 60 patients each, with each group receiving one of two medical treatments: Tadalafil or Tamsulosin.

Results: Patients treated with tadalafil had a substantially shorter time to expel calculi than those treated with tamsulosin (13.1 vs 16.92 days; p0.05). On tadalafil, complete ejection was noted in 86.7 percent of cases compared to only 63.3 percent on tamsulosin (p0.05). In patients treated with tamsulosin, mean analgesic usage (2.69 vs 1.81; p0.05) and episodes of colicy pain (1.41 vs 0.43; p0.05) were considerably higher. Tamsulosin also needed more hospital visits throughout therapy (2.56 vs 2.02 days; p=0.06), but the difference was not statistically significant. There was no difference between the two medications' adverse effect profiles.

Tadalafil also increases early stone evacuation, a reduction in colicky pain episodes, and a decrease in the need for analgesics. Both drugs are well tolerated, safe, and effective, with only modest side effects. Tadalafil is thus a safe, effective, and well-tolerated medicinal expulsive therapy for distal ureteric stones.


Author(S) Details

Vipul Gurjar
SBKS MIRC, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.

Bhavin Shah
SBKS MIRC, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.

View Book:- https://stm.bookpi.org/IDMMR-V9/article/view/5858