Background: Cholelithiasis, i.e., gallstone disease (GSD), is one of the most common gastrointestinal disorders. apolipoprotein A1 (ApoA1), In other studies, ApoE, Mucin1 and cholesterol ester transfer protein (CETP) were implicated with cholelithiasis. However, these results were variable and needed confirmation by further research.
Objective: This study evaluates the associations of Mucin1 and
cholesterol ester transfer protein (CETP) between normal control subjects (NCs)
and Cholelithiasis, i.e. gallstone disease (GSD) patients (Pts) preoperatively
(I0) and postoperatively (II0) with laparoscopic cholecystectomy.
Methods: Adult Pts (N=55, Gender: 10 males, 45 females; Age range:
25-65 years, Mean age±SD: 45.5 ± 12.2 years) were those reported in our previous
case-control prospective interventional studies carried out from October 2016
to March 2018 at MRU, MHWT, Uttara, Dhaka, Bangladesh. The patients with GSD
were diagnosed as having cholelithiasis according to standard clinical and
laboratory criteria as practised in the hospital. The lipid profile (TG, TC,
LDL-C, HDL-C), Lp (a), ApoA1, ApoB100, ApoE, Mucin1 and CETP status in serum of
NCs and Pts (I0, II0) and Pts-Bile (I0) were made by standard clinical
laboratory methods using research/diagnostics kits from reputed companies and
reported in the recent past. Recently, further advanced statistical analyses on
these data were made according to the objectives of the present article, i.e.
to obtain information regarding associations (correlations) between serum
Mucin1 and CETP status among NCs and Pts (I0, II0) by using the SPSS programme
version 26.
Results: Regarding associations (correlations) between Mucin1 and
CETP status among NCs (I0) and Pts (I0) and Pts (II0), significant Pearson
correlations were found for Pts-Mucin1 (I0) vs Pts-CETP (I0) (r=0.316,
p=0.019), Pts-Mucin1 (Bile-I0) vs Pts-CETP (Bile-I0) (r=0.441, p=0.005),
Pts-Mucin1 (II0) vs Pts-CETP (I0) (r=0.398, p=0.007), Pts-Mucin1 (I0) vs
Pts-CETP (II0) (r=0.335, p=0.017) and NCs-Mucin1 (I0) vs Pts-CETP (Bile-10)
(r=0.375, p=0.048). No significant correlations were observed between any of
the other groups compared (P>0.05).
Conclusions: The observations on associations between Mucin1 and
CETP among NCs and Pts (I0, II0) suggested their probable involvement in the
aetiopathogenesis of the disease. Since GSD is one of the most prevalent
diseases in gastroenterology, an appropriate diagnostic approach and management
in clinical practice, such as medical treatment and surgical intervention
depending on the patient’s condition, should be adopted. Considering the
complexity of the molecular mechanisms in the formation of gallstones, further
studies on GSD are certainly warranted, particularly involving a larger number
of Bangladeshi patients in the future.
Author(s)
Details
A. S.
M. Giasuddin
Impulse Hospital, ImHS&RC Ltd, 304/E, Tejgaon Industrial Area,
Dhaka-1208, Bangladesh.
K. A.
Jhuma
Dhaka Medical College, Dhaka-1000, Bangladesh.
M. A.
M. Choudhury
Department of Surgery, MCW&H, MHWT, Plot-4, Road-8/9,
Sector-1, Uttara Model Town, Dhaka-1230, Bangladesh.
A. M.
M. Haq
Department of Internal Medicine, MCW&H and Chairman of MRU,
MCN&H, MHWT, Uttara, Dhaka-1230, Bangladesh.
Please
see the book here:- https://doi.org/10.9734/bpi/msraa/v7/5598
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