The solubilisation of poorly water-soluble drugs is a critical
aspect of chemical screening and formulation research. Various techniques are
employed to enhance the water solubility of such drugs, and among these
techniques, hydrotropic solubilization is one of the most effective methods.
Hydrotropes are compounds that help dissolve hydrophobic substances in aqueous
solutions without causing problems related to emulsification, which is common
in surfactant solutions. This method is highly suitable for industrial
applications because solutes can be easily retrieved and hydrotrope solutions
can be reused. Hydrotropes exhibit pH-independent solvent properties, and high
selectivity, and are nonflammable, affordable, and easily obtainable. These
factors make this technique superior to other solubilization methods. This
study introduces hydrotropy, focusing on its generation, with a detailed
account of various techniques for improving its solubility. Hydrotropic
solubilisation is a viable and economically attractive strategy for enhancing
the aqueous solubility of poorly water-soluble drugs, which is highly
beneficial for pharmaceutical formulations and achieving recognition of its
potential in the industry.
Author(s) Details
R.
Senthilkumar
College of Engineering and Technology, University of Technology
and Applied Sciences-Suhar. PO Box 135, Postal code 311-Suhar, Sultanate of
Oman.
R.
Sridhar
Department of Chemical Engineering, Pondicherry Engineering
College, Pillaichavadi, Puducherry –605 014, India.
G.
Surendran
Department of Chemical Engineering, KPR Institute of Engineering
and Technology, Coimbatore, India.
C.
Jayakumar
Department of Applied Science and Technology, A.C.Tech, Anna
University, Chennai-600025, India.
Please
see the book here:- https://doi.org/10.9734/bpi/prrat/v5/1935
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