Hydrotropic Solubilization: A Promising Approach for Enhancing the Solubility of Poorly Water-Soluble Drugs | Chapter 10 | Pharmaceutical Research: Recent Advances and Trends Vol. 5

 

The solubilisation of poorly water-soluble drugs is a critical aspect of chemical screening and formulation research. Various techniques are employed to enhance the water solubility of such drugs, and among these techniques, hydrotropic solubilization is one of the most effective methods. Hydrotropes are compounds that help dissolve hydrophobic substances in aqueous solutions without causing problems related to emulsification, which is common in surfactant solutions. This method is highly suitable for industrial applications because solutes can be easily retrieved and hydrotrope solutions can be reused. Hydrotropes exhibit pH-independent solvent properties, and high selectivity, and are nonflammable, affordable, and easily obtainable. These factors make this technique superior to other solubilization methods. This study introduces hydrotropy, focusing on its generation, with a detailed account of various techniques for improving its solubility. Hydrotropic solubilisation is a viable and economically attractive strategy for enhancing the aqueous solubility of poorly water-soluble drugs, which is highly beneficial for pharmaceutical formulations and achieving recognition of its potential in the industry.

 

Author(s) Details

R. Senthilkumar
College of Engineering and Technology, University of Technology and Applied Sciences-Suhar. PO Box 135, Postal code 311-Suhar, Sultanate of Oman.

 

R. Sridhar
Department of Chemical Engineering, Pondicherry Engineering College, Pillaichavadi, Puducherry –605 014, India.

 

G. Surendran
Department of Chemical Engineering, KPR Institute of Engineering and Technology, Coimbatore, India.

 

C. Jayakumar
Department of Applied Science and Technology, A.C.Tech, Anna University, Chennai-600025, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/prrat/v5/1935

 

Recent Advances in Solubility Enhancement Techniques for Poorly Soluble Drugs | Chapter 8 | Pharmaceutical Research: Recent Advances and Trends Vol. 10

This review discusses the recent advances in solubility enhancement techniques aimed at improving the therapeutic efficacy and bioavailability of poorly soluble drugs. The key techniques include particle size reduction, nanosuspensions, and cryogenic approaches. Particle size reduction, through processes such as micronization and high-pressure homogenization, increases the drug surface area and enhances dissolution rates. Nanosuspensions, with particle sizes in the nanometer range, improve solubility by increasing surface energy and preventing drug aggregation. Cryogenic techniques such as spray freezing and ultra-rapid freezing enable the formation of amorphous or nanostructured drug particles, further promoting solubility. These techniques play a crucial role in overcoming formulation challenges, particularly for Biopharmaceutics Classification System (BCS) Class II and IV drugs, ultimately leading to improved bioavailability and therapeutic outcomes.

 

Author (s) Details

 

Sanagarapu Nageswarrao
Department of Pharmaceutical Analysis, Anurag Pharmacy College (Affiliated to JNTUH, Hyderabad), Kodad, Telangana, India.

 

Jagadish Lakamalla
Department of Pharmaceutical Analysis, Anurag Pharmacy College (Affiliated to JNTUH, Hyderabad), Kodad, Telangana, India.

 

M. Chinna Eswaraiah
Department of Pharmacognosy, Anurag Pharmacy College (Affiliated to JNTUH, Hyderabad), Kodad, Telangana, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/prrat/v10/3398

Determination of Solid Dispersion by Fluidized Bed Processing: A Platform for Enhancement of Solubility and Dissolution | Chapter 10 | Current Aspects in Pharmaceutical Research and Development Vol. 8

 This comprehensive article discusses fluidized bed processing as a novel way for improving the solubility of pharmaceuticals that are insufficiently water-soluble. The major goal of this research was to use the fluidized bed processing technique to investigate the solubility and dissolution kinetics of the poorly water-soluble medication simvastatin from its solid dispersion with various carriers. Drug solubility is one of the most critical barriers to achieving desired medication convergence in the blood. Around 40% of all new and existing medicine up-and-comers are lipophilic in nature and fail to reach useful levels due to poor solubility, resulting in sluggish dissolution and inadequate bioavailability. The drug characteristics, ingestion site, and needed dose structure attributes all influence which solubility upgrade process is used. Simvastatin is BCS class- II, meaning it is poorly soluble and permeable, reducing its bioavailability. To address this issue, a solid dispersion is created using various techniques with a polymeric carrier to potentially improve solubility and dissolution rate, such as fluidized bed processing. This will increase drug absorption, so the goals were to compare different solid dispersions and assess the effect of various carriers in extending drug absorption. In order to boost the bioavailability of weakly water-soluble medicines, Gelucire® 44/14, PVP- K30, and Poloxamer were used as carriers. The dissolution profiles were associated using a variety of mathematical models, including zero order, first order, Higuchi, and Hixon Crowell, with the Zero order kinetics model outperforming the others. When compared to the pure medication and alternative carriers, the dissolution profile of SIM was greatly enhanced when complexed with Gelucire 44/14. The dissolving rate and solubility profile of the binary system produced with FBP were the greatest. It was also discovered that all SIM SDs had a much higher dissolution rate and solubility than both PMs, and that the dissolution rate of both PMs was higher than pure simvastatin.

Author(S) Details

Rajendra K. Surawase
Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Kalwan, Nashik, MS, India.

Kamalkishor G. Baheti
Maulana Azad Educational Trust’s Y. B. Chavan College of Pharmacy, Aurangabad, MS, India.

View Book:- https://stm.bookpi.org/CAPRD-V8/article/view/5651